Lafoensia pacari alleviates intestinal damage by modulating cyclooxygenase-2: In silico and in vivo evaluation in a colitis model

Figure 1 Antinociceptive activity of keto-alcoholic extracts of Lafoensiapacari. A: Keto-alcoholic extracts of leaves; B: Keto-alcoholic extracts of bark; C: Time-dependent action of the keto-alcoholic extract of Lafoensia pacari (L. pacari) leaves at 100 mg/kg; D: Time-dependent action of the keto-alcoholic extract of L. pacari bark at 100 mg/kg. Results presented ± representative error of 8 animals per group. ^aP < 0.05 vs saline group; ^cP < 0.05 vs DMSO 2% (v/v), acetic acid; ^eP < 0.05 vs all groups except the saline group. One-way analysis of variance followed by Tukey's t-test. Error bar: Standard error of the mean; L. pacari: Lafoensia pacari.