Immunotherapy for recurrent hepatocellular carcinoma

Table 1 Immunotherapy regimens for first-line use in patients with advanced hepatocellular carcinoma with no prior systemic therapy

Immunotherapy regimen	IMBRAVE150 (NCT03434379)	HIMALAYA (NCT03298451)
Drugs	Atezolizumab, Bevacizumab	Durvalumab, Tremelimumab
Drug class combination	PD-L1 inhibitor, VEGF inhibitor	PD-1 inhibitor, CTLA-4 inhibitor
Study population	Child-Pugh A, ECOG score 0/1, no prior systemic therapy	Child-Pugh A, ECOG score 0/1, BCLC B or C, no prior systemic therapy
Key difference	Portal vein thrombosis patients included	Portal vein thrombosis patients excluded
EGD required?	Yes	No
Overall survival	19.2 mo (95%CI: 17.0-23.7)	16.4 mo (95%CI: 14.2-19.6)
Median progression free survival	6.8 mo (95%CI: 5.7-8.3) vs 4.3 (95%CI: 4.0-5.6)	3.8 mo (95%CI: 3.7-5.3)
Overall response rate	27.3% (95%CI: 22.5-32.5)	STRIDE arm: 20.1%
Long-term survival data	Not available	Available

BCLC: Barcelona Clinic Liver Cancer; CI: Confidence interval; CTLA-4: Cytotoxic T lymphocyte associated protein-4; ECOG: Eastern Cooperative Oncology Group; EGD: Esophagogastroduodenoscopy; FDA: Food and Drug Administration; PD-1: Programmed cell death protein-1; PD-L1: Programmed death- ligand 1; STRIDE: Single Tremelimumab Regular Interval Durvalumab; VEGF: Vascular endothelial growth factor.