Clinical outcomes of lenvatinib plus transarterial chemoembolization with or without programmed death receptor-1 inhibitors in unresectable hepatocellular carcinoma

doi:10.3748/wjg.v29.i10.1614

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Mar 14, 2023 (publication date) through May 19, 2024

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World Journal of Gastroenterology

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1007-9327

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Retrospective Study

World J Gastroenterol. Mar 14, 2023; 29(10): 1614-1626
Published online Mar 14, 2023. doi: 10.3748/wjg.v29.i10.1614

Table 1 The baseline characteristics of included patients (n, %)

	Overall	Lenvatinib + TACE + PD-1	Lenvatinib + TACE	P value
Patient characteristics
Number (n)	65	45	20
Age, median (range), yr	57 (18-79)	54 (18-79)	62 (26-75)	0.066¹
< 65	50 (76.92)	38 (84.44)	12 (60.00)
≥ 65	15 (23.08)	7 (15.56)	8 (40.00)
Gender				0.095¹
Female	8 (12.31)	3 (6.67)	5 (25.00)
Male	57 (87.69)	42 (93.33)	15 (75.00)
ECOG-PS				0.154¹
0	33 (50.77)	26 (57.78)	7 (35.00)
1	32 (49.23)	19 (42.22)	13 (65.00)
Etiology				0.002¹
HBV	54 (83.08)	42 (93.33)	12 (60.00)
HCV	4 (6.15)	2 (4.44)	2 (10.00)
Non-HBV, non-HCV	7 (10.77)	1 (2.22)	6 (30.00)
Hepatic cirrhosis				0.879¹
Yes	43 (66.15)	29 (64.44)	14 (70.00)
No	22 (33.85)	16 (35.56)	6 (30.00)
AFP				0.551¹
< 400	21 (32.31)	13 (28.89)	8 (40.00)
≥ 400	44 (67.69)	32 (71.11)	12 (60.00)
Child-Pugh score				0.095¹
A5	48 (73.85)	30 (66.67)	18 (90.00)
A6 or B7	17 (26.15)	15 (33.33)	2 (10.00)
BCLC stage				1.000¹
A or B	16 (24.62)	11 (24.44)	5 (25.00)
C	49 (75.38)	34 (75.56)	15 (75.00)
Tumor characteristics
Tumor size				0.035¹
< 7 cm	25 (38.46)	13 (28.89)	12 (60.00)
≥ 7 cm	40 (61.54)	32 (71.11)	8 (40.00)
Tumor number				0.260¹
Single	21 (32.31)	17 (37.78)	4 (20.00)
Multiple	44 (67.69)	28 (62.22)	16 (80.00)
TBS group				0.173¹
L	23 (35.38)	13 (28.89)	10 (50.00)
H	42 (64.62)	32 (71.11)	10 (50.00)
Portal vein tumor thrombus				0.108¹
Presence	24 (36.92)	20 (44.44)	4 (20.00)
Absence	41 (63.08)	25 (55.56)	16 (80.00)
Extrahepatic metastasis				0.376¹
Yes	23 (35.38)	18 (40.00)	5 (25.00)
No	42 (64.62)	27 (60.00)	15 (75.00)
TACE times				0.260¹
< 3	44 (67.69)	28 (62.22)	16 (80.00)
≥ 3	21 (32.31)	17 (37.78)	4 (20.00)

¹χ² test.

AFP: Alpha-fetoprotein; BCLC: Barcelona Clinic Liver Cancer; ECOG-PS: Eastern Cooperative Oncology Group performance status; HBV: Hepatitis B virus; HCV: Hepatitis C virus; PD-1: Programmed death receptor-1; TACE: Transarterial chemoembolization; TBS: Tumor burden score.

Citation: Wang YY, Yang X, Wang YC, Long JY, Sun HS, Li YR, Xun ZY, Zhang N, Xue JN, Ning C, Zhang JW, Zhu CP, Zhang LH, Yang XB, Zhao HT. Clinical outcomes of lenvatinib plus transarterial chemoembolization with or without programmed death receptor-1 inhibitors in unresectable hepatocellular carcinoma. World J Gastroenterol 2023; 29(10): 1614-1626
URL: https://www.wjgnet.com/1007-9327/full/v29/i10/1614.htm
DOI: https://dx.doi.org/10.3748/wjg.v29.i10.1614