In vivo recognition of bioactive substances of Polygonum multiflorum for protecting mitochondria against metabolic dysfunction-associated fatty liver disease

Figure 2 Effects of Polygonum multiflorum extract on serum biochemical parameters of high-fat diet-fed rats. Sprague Dawley rats were administered saline, resveratrol, or Polygonum multiflorum extract (2, 4 or 8 g/kg/d). After 3 mo of high-fat diet feeding, rats were sacrificed, and serum was collected. A: Serum levels of total cholesterol were determined using a commercial kit; B: Serum levels of triglyceride were determined using a commercial kit; C: Serum levels of alanine transaminase were determined using a commercial kit; D: Serum levels of aspartate transaminase were determined using a commercial kit; E: Serum levels of low-density lipoprotein cholesterol were determined using a commercial kit; F: Serum levels of high-density lipoprotein cholesterol were determined using a commercial kit. Values represent the mean ± SD from six animals. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001 vs model group. ALT: Alanine transaminase; AST: Aspartate transaminase; HDL-C: High-density lipoprotein cholesterol; HPM: High-dose Polygonum multiflorum extract; LDL-C: Low-density lipoprotein cholesterol; LPM: Low dose Polygonum multiflorum extract; MOD: Model; MPM: Middle-dose Polygonum multiflorum extract; NC: Normal control; RES: Resveratrol; TC: Total cholesterol; TG: Triglyceride.