In vivo recognition of bioactive substances of Polygonum multiflorum for protecting mitochondria against metabolic dysfunction-associated fatty liver disease

Table 1 Effects of Polygonum multiflorum extract on body weight, food intake, and organ indices of high-fat diet-fed rats

	NC	MOD	RES	LPM	MPM	HPM
Initial body weight (g)	263.67 ± 23.43	263.83 ± 28.54	261.50 ± 16.99	275.83 ± 6.05	268.83 ± 12.42	246.00 ± 15.09
Final body weight (g)	458.67 ± 46.43	470.17 ± 89.14	424.67 ± 25.97	454.67 ± 16.98	479.83 ± 33.88	432.83 ± 47.94
Body weight gain (g)	195.00 ± 23.00	206.33 ± 60.60	163.17 ± 8.98	178.83 ± 10.93	211.00 ± 21.46	186.83 ± 32.86
Food intake (g)	15852.54	14023.10	14265.09	13828.25	13081.76	13645.74
Liver index (%)	2.15 ± 0.09b	2.64 ± 0.22	2.32 ± 0.12a	2.55 ± 0.11	2.49 ± 0.16	2.49 ± 0.20
Kidney index (%)	0.52 ± 0.02	0.54 ± 0.07	0.52 ± 0.02	0.50 ± 0.02	0.49 ± 0.03	0.54 ± 0.04
Spleen index (%)	0.1589 ± 0.01	0.1618 ± 0.02	0.1432 ± 0.01	0.1267 ± 0.01b	0.1427 ± 0.01	0.1345 ± 0.01a

^aP < 0.01 vs model group.

^bP < 0.001 vs model group.

Values represent the mean ± SD from six animals. HPM: High-dose Polygonum multiflorum extract; LPM: Low dose Polygonum multiflorum extract; MOD: Model; MPM: Middle-dose Polygonum multiflorum extract; NC: Normal control; RES: Resveratrol.