Postoperative outcomes and recurrence patterns of intermediate-stage hepatocellular carcinoma dictated by the sum of tumor size and number

Table 2 Univariate and multivariate analysis of overall survival in patients with Barcelona Clinic Liver Cancer stage B hepatocellular carcinoma

Variables	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Gender (male)	1.128 (0.409-3.117)	0.816
Age (> 65 yr)	0.668 (0.285-1.562)	0.352
BMI > 25	0.954 (0.513-1.772)	0.880
HBs-Ag positive	1.084 (0.466-2.525)	0.851
ALBI grade
1	1.00 (Reference)		1.00 (Reference)
2	1.891 (1.112-3.217)	0.019	2.279 (1.236-4.201)	0.008
AFP > 400 ng/mL	1.969 (1.165-3.327)	0.011
Maximum tumor size > 5 cm	2.510 (1.354-4.651)	0.003
Tumor number > 3	3.806 (1.716-8.444)	0.001	5.519 (2.207-13.803)	< 0.001
N + S > 10	3.403 (2.031-5.702)	< 0.001	2.996 (1.779-5.045)	< 0.001
Bilateral tumor distribution	2.201 (1.312-3.694)	0.003
Presence of MVI	1.816 (0.855-3.858)	0.120
Edmondson-Steiner III-IV	2.084 (1.248-3.480)	0.005	2.051 (1.219-3.449)	0.007
Major resection	1.886 (1.115-3.191)	0.018
NAH	0.905 (0.458-1.788)	0.775
Preoperative TACE
No	1.00 (Reference)
Yes	0.494 (0.198-1.238)	0.132

BMI: Body mass index; HBs-Ag: Hepatitis B surface antigen; ALBI: Albumin-bilirubin; AFP: Alpha-fetoprotein; N + S: The sum of tumor size and number; MVI: Microvascular invasion; NAH: Non-anatomical hepatectomy; TACE: Transarterial chemoembolization.