Pancreatic acinar cell carcinoma: A comprehensive review

Figure 1 Histopathological patterns. A: Acinar cell carcinoma with the predominant acinar pattern. The acinar pattern is characterized by structures resembling normal acini, with small lumina and cells arranged in a monolayer with basally located nuclei; B: Acinar cell carcinoma with the predominant glandular pattern. Acinar structures with dilated lumina characterize the glandular pattern; C: Acinar cell carcinoma with the predominant trabecular pattern. The trabecular pattern is characterized by ribbons of cells resembling those of pancreatic neuroendocrine tumors; D: Acinar cell carcinoma with a predominant solid pattern. Large sheets of cells characterize the solid pattern without lumina; E: Acinar cell carcinoma, immunohistochemical staining for trypsin; F: Acinar cell carcinoma, immunohistochemical staining for cytokeratin 7.