P2X7 receptor as the regulator of T-cell function in intestinal barrier disruption

Figure 3 P2X7 receptor on dendritic cells and T cells influences the fate of T cells indirectly or directly, respectively. The activation of P2X7 receptor on dendritic cells induces the maturation and migration of cells and promotes the inflammasome activation, affecting the activation and differentiation of T cells finally. The activation of P2X7 receptor in T cells can directly regulate the activation, differentiation, migration and homeostasis of T cells[33].