Gastrointestinal tumors in transplantation: Two case reports and review of literature

Table 2 Clinical features and immunosuppression regimen of 16 transplant patients with gastrointestinal stromal tumor

Ref.	Age (yr)/sex	Transplanted organ	Time from transplantation to diagnosis	Location of primitive GIST	Metastasis at diagnosis		Evolution/delay	Immunosuppression before diagnosis	Immunosuppression after diagnosis
Agaimy and Wünsch[11]	59/F	Kidney	40 mo	Stomach	No	Relapse 68 mo		Not described	Not described
Agaimy and Wünsch[11]	58/F	Kidney	96 mo	Small bowel	No	Not described		Not described	Not described
Saidi et al[19]	54/M	Liver	11 mo	Colon	No	Not described		Tac, Aza	Not described
Camargo et al[22]	64/M	Liver	7 mo	Perineum	No	Not described		Tac, mycophenolate sodium	Not described
Tu et al[18]	57/F	Kidney	6 mo	Pelvis	No	Not described		Steroids, CsA, MMF	CsA and MMF at half dosage; rapamycin-containing regimensteroids withdrawn
Mulder et al[12]	72/M	Kidney	21 yr	Stomach	No	Peritoneal metastasis/24 mo		Steroids, CsA	Steroids, CsA (60% reduction in dosage)
Mrzljak et al[20]	53/M	Liver	12 mo	Jejunum	No	No		Tac, MMF	Same
Cimen et al[13]	46/F	Kidney	18 yr	Stomach	No	Not described		Steroids, CsA, Aza	Same with reduced dosage of CsA
Cheung et al[14]	64/M	Kidney	2 yr	Stomach	No	Yes/2 yr		Steroids, Tac, MMF	Steroids, Tac (reduced dosage), everolimus
Cheung et al[14]	48/M	Kidney	1 yr	Mesentery	Multiple tumors	No		CsA, MMF	CsA withdrawal, sirolimus introduction
Patiño et al[15]	23/F	Kidney	13 yr	Stomach	No	Local relapse/3 yr		Steroids, Tac, MMF	Not described
Xie et al[21]	60/M	Liver	11 mo	Stomach	No	No		Tac, sirolimus, MMF	Same
Elkabets et al[17]	74/M	Kidney	7 yr	Stomach	No	No		Steroids, CsA, MMF	Switch CsA to mTOR inhibitor
Takahashi et al[16]	64/M	Kidney	72 mo	Small bowel	No	No		Steroids, CsA, MMF	Stop CsA
Stammler et al	60/M	Kidney	5 mo	Stomach	No	No		Steroids, Tac, MMF	Switch MMF to belatacept
Stammler et al	64/M	Kidney	51 mo	Stomach	No	Yes/23 mo		Steroids, CsA, MMF	Switch CsA to Tac

Aza: Azathioprine; CsA: Cyclosporine; F: Female; GIST: Gastrointestinal stromal tumor; M: Male; MMF: Mycophenolate mofetil; mTOR: Mammalian target of rapamycin; Tac: Tacrolimus.