Machine learning predicts portal vein thrombosis after splenectomy in patients with portal hypertension: Comparative analysis of three practical models

Table 2 Univariate and multivariate logistic regression analyses for risk factors associated with portal vein thrombosis in the overall cohort

Variable	Univariate		Multivariate1
	OR (95%CI)	P value	OR (95%CI)	P value
Sex (female vs male)	1.18 (0.79-1.76)	0.42
Age (< vs ≥ 60 yr)	0.68 (0.40-1.16)	0.16
Smoking (no vs yes)	1.15 (0.73-1.81)	0.56
Alcohol (no vs yes)	0.96 (0.59-1.56)	0.86
RBC2 (× 1012/L)	0.71 (0.44-1.14)	0.16
HLB2 (g/L)	1.01 (0.99-1.02)	0.22
WBC2 (× 109/L)	0.87 (0.76-1.00)	0.05
N2 (× 109/L)	1.05 (0.98-1.12)	0.20
L2 (× 109/L)	0.27 (0.16-0.45)	< 0.001	0.28 (0.14-0.54)	< 0.001
NLR2	1.07 (1.01-1.14)	0.03	1.03 (0.98-1.11)	0.42
PLT2 (× 109/L)	0.98 (0.97-0.99)	< 0.001	0.99 (0.98-1.01)	0.98
PLR2	1.00 (1.00-1.00)	0.18
PT2 (s)	0.94 (0.89-1.00)	0.07
PTA2 (%)	0.97 (0.96-0.99)	< 0.001	0.99 (0.98-1.02)	0.73
INR2	0.98 (0.88-1.09)	0.74
FIB2 (g/L)	1.06 (0.93-1.21)	0.42
APTT2 (s)	0.99 (0.96-1.01)	0.38
ALT2 (U/L)	0.99 (0.98-1.00)	0.16
AST2 (U/L)	0.98 (0.97-0.99)	< 0.001	0.99 (0.98-1.00)	0.14
ALB2 (g/L)	1.00 (0.97-1.04)	0.97
TBIL2 (μmol/L)	1.00 (0.99-1.02)	0.78
Child-Pugh (A vs B)	0.88 (0.59-1.33)	0.56
EGV (no vs yes)	0.48 (0.33-0.69)	< 0.001	0.51 (0.32-0.79)	0.003
SPT2 (cm)	1.34 (1.19-1.50)	< 0.001	1.22 (1.06-1.40)	0.005
DPV2 (cm)	4.72 (2.69-8.29)	< 0.001	3.57 (1.86-7.03)	< 0.001
PBT (no vs yes)	1.78 (1.17-2.70)	0.01	1.33 (0.79-2.26)	0.28
De (no vs yes)	1.09 (0.53-2.25)	0.81
PLT12 (× 109/L)	1.00 (0.99-1.00)	0.32
PLT32 (× 109/L)	1.00 (1.00-1.00)	0.25
PPER2 (%)	2.77 (2.1-3.66)	< 0.001	1.78 (1.24-2.62)	0.002
PPER32 (%)	1.86 (1.58-2.19)	< 0.001	1.43 (1.16-1.77)	< 0.001

¹Forward stepwise analysis.

²Continuous variables.

PVT: Portal vein thrombosis; OR: Odds ratio; CI: Confidence interval; RBC: Red blood cells; HLB: Hemoglobin; WBC: White blood cells; N: Neutrophil count; L: Lymphocyte count; NLR: Neutrophil to lymphocyte ratio; PLT: Platelet count; PLR: Platelet to lymphocyte ratio; PT: Prothrombin time; PTA: Prothrombin activity; INR: International normalized ratio; FIB: Fibrinogen; APTT: Activated partial thromboplastin time; ALT: Alanine aminotransaminase; AST: Aspartate aminotransaminase; ALB: Serum albumin; TBIL: Total serum bilirubin; EGV: Esophageal and gastric varices; SPT: Spleen thickness; DPV: Diameter of the portal vein; PBT: Preoperative blood transfusion; De: Devascularization; PLT1: Platelet count at postoperative day 1; PLT3: Platelet count at postoperative day 3; PPER1: Platelet elevation rate at postoperative day 1; PPER3: Platelet elevation rate at postoperative day 3.