Serological profiling of Crohn’s disease and ulcerative colitis patients reveals anti-microbial antibody signatures

Figure 2 Sequence homology of target antigens of validated antibodies and overlap of antibodies among Crohn’s disease and ulcerative colitis. A: Heatmap showing sequence homology among target antigens for antibodies with validated performance of ≥ 14% sensitivity at 96% specificity comparing Crohn’s disease (CD) patients with healthy controls; B: CD_IgG, ulcerative colitis (UC)_IgG, CD_IgA and UC_IgG represent the overlap of anti-microbial antibodies of IgG and IgA isotypes in CD and UC patients with ≥ 14% sensitivity at 96% specificity against healthy controls in the discovery set. CD: Crohn’s disease; UC: Ulcerative colitis.