Network meta-analysis of randomized controlled trials on esophagectomies in esophageal cancer: The superiority of minimally invasive surgery

Table 1 Baseline characteristics of the included studies

Ref.	Year	Country	Design	Compared interventions	Number of patients	Male/female ratio	Age in yr, mean	Squamous cell cancer/adenocarcinoma ratio	Inclusion criteria
Straatman et al[25]	2012	Netherlands, Spain, Italy	Multicenter	MI-TT	59-56	43/16-46/17	62.3–61.8	24/35-19/36	cT1-3, N0-1, M0
van der Sluis et al[26]	2019	Netherlands	Single center	RA-TT	54-55	46/8-42/13	64-65	13/41-12/43	T1-4a, N0-3, M0
Mariette et al[27]	2019	France	Multi center	H-TT	103-104	88/15-175/32	59-61 (median)	46/57-84/123	T1-3, N0-1, M0
Guo et al[28]	2013	China	Single center	MI-TT	111-110	68/43-72/38	57.3-60.8	No information	T1-3, N0-1, M0
Ma et al[29]	2018	China	Single center	MI-TT	47-97	36/11-83/14	61-59.3	43/0-91/2	Resectable cancer
Jacobi et al[30]	1997	Germany	Single center	TH-TT	16-16	No information	54-55	13/3-13/3	Resectable cancer
Goldminc et al[31]	1993	Australia	Single center	TH-TT	32-35	31/1-33/2	57.4-57.4	32/0-35/0	Resectable squamous cell cancer
Chu et al[32]	1997	China	Single center	TH-TT	20-19	18/2-17/2	60.7-63.9	No information	Lower third resectable cancer
Hulscher et al[33]	2002	Netherlands	Multicenter	TH-TT	106-114	92/14-97/17	69-64	0/106-0/114	Resectable adenocarcinoma
Yang et al[35]	2016	China	Single center	MI-TT	120-120	82/38-87/33	62.5 -67.8	75/45-72/48	T1-3, N0-1, M0
Paireder et al[34]	2018	Austria	Single center	H-TT	14-12	10/4-10/2	64.5-62.5 (median)	4/10-1/11	Siewert I-II, resectable squamous cell cancer

Number of patients, male/female ratio, age, and ratio of squamous cell cancer and adenocarcinoma are presented according to the compared interventional arms. H: Hybrid esophagectomy; MIE: Minimally invasive esophagectomy; RA: Robot assisted esophagectomy; TH: Transhiatal esophagectomy; TT: Transthoracic esophagectomy.