Microbiome changes in the gastric mucosa and gastric juice in different histological stages of Helicobacter pylori-negative gastric cancers

Table 1 Relative abundance of the selected top 34 genera in different histological stages

	Relative abundance (%)
	SG	AG	IM	Dys	GC	One-way ANOVA, P value	P value
g__Ralstonia	10.43	3.84	31.05	31.04	7.97	0.000	0.008b; 0.004c
g__Streptococcus	7.52	9.19	7.91	4.28	14.90	0.028	0.013d
g__Prevotella	5.81	7.83	3.82	3.40	5.70	0.111
g__Lactobacillus	4.56	6.42	1.16	2.57	9.23	0.009
g__Neisseria	3.80	1.05	6.03	2.81	2.36	0.538
g__Veillonella	3.15	3.00	2.31	1.49	4.53	0.497
g__Burkholderia-Caballeronia-Paraburkholderia	1.93	1.06	2.93	3.45	1.72	0.043
g__Haemophilus	2.95	0.78	2.08	1.32	2.33	0.540
g__Alloprevotella	2.05	1.54	1.51	1.06	1.39	0.373
g__Acinetobacter	1.74	0.96	1.12	1.78	1.93	0.716
g__Actinomyces	1.42	2.80	1.04	0.92	1.22	0.364
g__Escherichia-Shigella	1.86	1.12	1.11	1.70	1.47	0.193
g__Fusobacterium	1.85	0.96	1.57	0.97	1.29	0.308
g__Pseudomonas	1.56	0.47	0.88	1.65	1.70	0.128
g__Porphyromonas	2.14	0.53	1.38	0.78	1.32	0.259
g__Geobacillus	1.68	0.99	0.52	1.25	1.12	0.022
g__Bifidobacterium	0.50	1.53	0.18	0.72	2.09	0.001	0.015d
g__Rhodococcus	0.50	0.29	2.11	1.79	0.11	0.003	0.008b; 0.038c
g__Gemella	0.93	1.18	0.63	0.32	1.39	0.119
g__Delftia	1.07	0.35	0.95	0.90	1.04	0.609
g__Granulicatella	0.86	0.45	1.08	0.52	1.15	0.659
g__Bacteroides	1.49	1.08	0.22	0.54	0.66	0.003
g__Leptotrichia	0.66	0.73	1.02	0.49	0.65	0.689
g__norank_f__Mitochondria	0.44	2.51	0.15	0.16	0.10	0.016	0.008a
g__Rothia	0.77	0.70	1.00	0.28	0.56	0.762
g__unclassified_p__Proteobacteria	0.49	1.03	0.64	0.28	0.12	0.195
g__Raoultella	0.03	0.02	0.81	1.60	0.00	0.000	0.002c
g__Sphingomonas	0.54	0.17	0.33	0.56	0.81	0.742
g__Blautia	0.83	0.86	0.18	0.23	0.32	0.001
g__Clostridium_sensu_stricto_1	0.24	0.43	0.30	0.81	0.54	0.292
g__TM7x	0.57	0.48	0.63	0.28	0.26	0.269
g__Corynebacterium	0.64	0.16	0.24	0.64	0.45	0.777
g__norank_f__norank_o__Chloroplast	0.63	0.53	0.33	0.22	0.30	0.924
g__Faecalibacterium	0.62	0.88	0.11	0.16	0.21	0.008

^aSG vs AG.

^bSG vs IM.

^cSG vs Dys.

^dSG vs GC. SG: Superficial gastritis; AG: Atrophic gastritis; IM: Intestinal metaplasia; Dys: Dysplasia; GC: Gastric cancer.