RING finger and WD repeat domain 3 regulates proliferation and metastasis through the Wnt/β-catenin signalling pathways in hepatocellular carcinoma

Figure 1 Expression of RING finger and WD repeat domain 3 in hepatocellular carcinoma and its correlation with a worse prognosis. A: RING finger and WD repeat domain 3 (RFWD3) expression in hepatocellular carcinoma (HCC) tumor and non-tumor tissues detected using immunohistochemical staining; B: Expression analysis of RFWD3 in 54 tissue sample pairs (some invalid samples were removed) using quantitative reverse transcription-polymerase chain reaction (^bP < 0.01); C: Comparison of RFWD3 expression between tumor and non-tumor tissues in HCC patients (T = 374, n = 50, the data source is the Cancer Genome Atlas (TCGA) (TCGA) database); D and E: Kaplan-Meier survival curves of HCC patients with high and low expression of RFWD3 (n = 91, the data source is the TCGA database).