RING finger and WD repeat domain 3 regulates proliferation and metastasis through the Wnt/β-catenin signalling pathways in hepatocellular carcinoma

Table 1 Clinicopathological features in hepatocellular carcinoma tissue microarrays

Clinicopathological parameters	Number	Expression of RFWD3		P value
		Low1	High1
Total	60	25	35
Gender
Male	24	9	15
Female	36	16	20	0.592
HBsAg
Positive	39	17	22
Negative	21	8	13	0.68
Age (yr)
< 60	34	17	17
≥ 60	26	8	18	0.134
Tumor size
< 5 cm	27	15	12
≥ 5 cm	33	10	23	0.048a
TNM stage2
I–II	31	17	14
III–IV	29	8	21	0.032a

¹Staining intensity (SI) × percentage of positive (PP) > 4 was considered high expression; SI × PP < 4 was considered low expression.

²TNM stage was determined according to the guidelines of the American Joint Committee on Cancer (2010).

^aP < 0.05.

RFWD3: RING finger and WD repeat domain 3.