New insights in diagnosis and treatment of gastroenteropancreatic neuroendocrine neoplasms

Figure 1 Ileal small cell neuroendocrine carcinoma with liver metastases in a 71-year-old man. A: Computed tomography (CT) image (axial) showing ileal and multifocal liver lesions (arrow); B: Positron emission tomography-CT image showing ileal (arrow) and liver lesions (arrowheads) with hypermetabolic activity; C: Histopathologic features of small cell neuroendocrine carcinoma. Note the tumor cells with peripheral palisading, rosetting, scant cytoplasm, nuclear molding, finely granular chromatin, and lack of prominent nucleoli; D-F: Tumor cells with positive immunoreactivity for synaptophysin (D) and CDX2 (E) as well as a high Ki-67 proliferation index (70%) (F). (C-F: 400 ×).