Forkhead Box q1 promotes invasion and metastasis in colorectal cancer by activating the epidermal growth factor receptor pathway

Table 2 List of up- and down-regulated genes between DLDL-shFOXQ1 and DLD1-shControl with a fold-change ≥ 2.0 or ≤ -2.0 by using epidermal growth factor/platelet-derived growth factor SuperArray

Symbol	Gene information	Fold change (shFOXQ1/shControl)	P value	FOXQ1 binding sites (TSS: -2k_+1k)
PLAT	Plasminogen activator, tissue	-8.01	0.0375	3
COL1A1	Collagen, type I, alpha 1	-5.72	0.0138	1
ELK1	ELK1, member of ETS oncogene family	-5.45	0.0228	1
BCAR1	Breast cancer anti-estrogen resistance 1	-3.97	0.0479	2
PIK3R2	Phosphoinositide-3-kinase, regulatory subunit 2	-3.63	0.0197	3
NCK2	NCK adaptor protein 2	-3.51	0.0237	6
JUN	Jun proto-oncogene v-jun	-3.43	0.0077	12
EGR1	Early growth response 1	-3.36	0.0166	11
LTA	Lymphotoxin alpha (TNF superfamily, member 1)	-3.18	0.0796	3
PDGFB	Platelet-derived growth factor beta	-2.91	0.1896	5
STAT3	Signal transducer and activator of transcription 3 (acute-phase response factor)	-2.49	0.0038	6
HB-EGF	Heparin-binding EGF-like growth factor	-2.19	0.0278	3
FN1	Fibronectin 1	-2.10	0.0005	6
FASLG	Fas ligand (TNF superfamily, member 6)	-2.08	0.2026	17
HRAS	V-Ha-ras Harvey rat sarcoma viral oncogene homolog	-2.06	0.0058	2
MAP2K1	Mitogen-activated protein kinase kinase 1	-2.02	0.0243	5
AKT3	V-akt murine thymoma viral oncogene homolog 3	-2.02	0.1440	11
FOS	FBJ murine osteosarcoma viral oncogene homolog	-2.01	0.0470	5