Hepatocellular adenoma: Where are we now?

Figure 1 Histologic features of hepatocellular adenoma. A: Hepatocyte nuclear factor 1A (HNF-1A) inactivated hepatocellular adenoma showing marked steatosis (Hematoxylin-eosin stain, original magnification 200 ×); B: HNF-1A inactivated hepatocellular adenoma showing loss expression of liver fatty acid binding protein in tumor component (Immunohistochemical stain, original magnification 200 ×); C: Inflammatory hepatocellular adenoma showing marked sinusoidal dilatation and pseudoportal tract with inflammatory infiltrate and ductular reaction (Hematoxylin-eosin stain, original magnification 200 ×); D: Inflammatory hepatocellular adenoma showing strong and diffuse expression of C-reactive protein in tumor component (Immunohistochemical stain, original magnification 200 ×); E: β-catenin activated hepatocellular adenoma showing mild cytologic atypia and pseudoacini (Hematoxylin-eosin stain, original magnification 200 ×); F: β-catenin activated hepatocellular adenoma showing nuclear expression of β-catenin in tumor component (Immunohistochemical stain, original magnification 400 ×); G: β-catenin activated hepatocellular adenoma showing strong and diffuse expression of glutamine synthetase in tumor component (Immunohistochemical stain, original magnification 200 ×); H: Pigmented hepatocellular adenoma showing marked cytoplasmic lipofuscin (Hematoxylin-eosin stain, original magnification 400 ×).