Effect of acetyl-L-carnitine on hypersensitivity in acute recurrent caerulein-induced pancreatitis and microglial activation along the brain’s pain circuitry

Figure 8 Microglia in the primary somatosensory cortex of mice with caerulein-induced pancreatitis were similar to those from controls. A: The analyzed area is outlined in yellow in an overview of the mouse brain at bregma -2.18 mm, interaural 1.62 mm[50,51]. B-E: Microglia in (B) naïve control and (C) caerulein- (CAE) induced pancreatitis mice had (D) similar convex areas and (E) staining intensity for ionized calcium-binding adaptor molecule 1 (Iba1); F and G: In fact, their somal areas were significantly decreased in animals with CAE-induced pancreatitis compared to naïve mice, and their Iba1 staining intensity was not different. Naïve control n = 4, CAE + VEH n = 5, ^aP < 0.05 Student’s t-test. CAE: Caerulein; VEH: Vehicle.