Effect of acetyl-L-carnitine on hypersensitivity in acute recurrent caerulein-induced pancreatitis and microglial activation along the brain’s pain circuitry

Figure 7 In the hypothalamic arcuate and dorsomedial nuclei, enlarged microglia were measured in mice with caerulein-induced pancreatitis. A: The analyzed area is outlined in yellow in an overview of the mouse brain at bregma -2.18 mm, interaural 1.62 mm[50,51]; B-D and F: Microglia in arcuate and dorsomedial nuclei of naïve control and (C) caerulein- (CAE) induced pancreatitis mice had (D) significantly different convex (samples circled in red in B and C) and (F) somal areas; E and G: Intensity of ionized calcium-binding adaptor molecule 1 (Iba1) immunoreactivity was not different. Naïve control n = 4, CAE + VEH n = 5, ^aP < 0.05 Student’s t-test. CAE: Caerulein; VEH: Vehicle.