Metabolomics of Fuzi-Gancao in CCl4 induced acute liver injury and its regulatory effect on bile acid profile in rats

Table 7 Variable importance in the projection values of serum metabolites and effects of Fuzi-Gancao on their changes (Fuzi-Gancao group vs model group)

Var ID (primary)	M1-VIP	Variation trend
Hypoxanthine	1.37706	↓↓
GSSG	1.36516	↓↓
Pantothenic acid	1.28548	↓↓
C18:1LPC	1.27880	↑↑
C16:1LPC	1.25881	↑↑
N-phenylacetylglycine	1.22022	↓↓
Lactate	1.21835	↓↓
Hippuric acid	1.21598	↓↓
Uric acid	1.21291	↓↓
(E)-butenedioic acid	1.21107	↓↓
Cholic acid	1.17091	↓↓
C18:0LPC	1.15078	↑↑
C16:0LPC	1.00088	↑
Choline	0.906949	NS
L-kynurenine	0.893225	↑↑
Uridine	0.810356	NS
8-OH-dG	0.777736	NS
Citric acid	0.633654	NS
GSH	0.512313	NS
L-leucine	0.497685	NS
Carnitine	0.447434	NS
Phenylalanine	0.427897	NS
Glucosamine-1-phosphate	0.312245	NS
L-tryptophan	0.0800812	NS

↑ represents a P value ≤ 0.05 for the increase in mean content; ↑↑ represents a P value ≤ 0.01 for the increase in mean content; ↓ represents a P value ≤ 0.05 for the mean content decrease; ↓↓ represents a P value ≤ 0.01 for the mean content decrease; NS: No statistically significant change in the mean concentration of metabolites in the Fuzi-Gancao group; GSSG: Glutathione oxidized; GSH: Glutathione; VIP: Variable importance in the projection.