Hepatitis B virus persistent infection-related single nucleotide polymorphisms in HLA regions are associated with viral load in hepatoma families

Figure 2 First-stage persistent hepatitis B virus infection. Genetic, nongenetic, and combined risk factors for persistent hepatitis B virus (HBV) infection were evaluated by area under the receiver operating characteristic curves derived from generalized estimating equation regression models. Significantly higher areas under the curve for nongenetic compared with genetic factors (P < 0.001) suggest that nongenetic factors played a major role in persistent HBV infection. AUC: Area under the receiver operating characteristic curve.