Hepatitis B virus persistent infection-related single nucleotide polymorphisms in HLA regions are associated with viral load in hepatoma families

doi:10.3748/wjg.v27.i37.6262

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Oct 7, 2021 (publication date) through Apr 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Gastroenterol. Oct 7, 2021; 27(37): 6262-6276
Published online Oct 7, 2021. doi: 10.3748/wjg.v27.i37.6262

Table 5 Multivariate generalized estimating equation and area under the curve hepatitis B viral loads in a hepatocellular family cohort

	Nongenetic model		Mixed model
Variable	OR (95%CI)	P value	OR (95%CI)	P value
SNP
Sex, male	1.955 (1.132-3.376)	0.0162	1.918 (1.101-3.341)¹/1.911 (1.097-3.328)²	0.0214¹/0.0223²
Index sex, male	0.903 (0.481-1.699)	0.7527	0.914 (0.488-1.713)¹/0.912 (0.482-1.725)²	0.7786¹/0.7771²
Age in yr	1.012 (0.987-1.037)	0.3363	1.007 (0.983-1.032)¹/1.008 (0.983-1.033)²	0.5658¹/0.5426²
Relation to index
Parent generation	4.182 (0.68-25.731)	0.1228	4.343 (0.81-23.285)¹/4.091 (0.75-22.316)²	0.0866¹/0.1036²
Index generation	1.7 (0.844-3.423)	0.1372	1.851 (0.912-3.756)¹/1.797 (0.894-3.611)²	0.0881¹/0.0999²
Index HBsAg+	2.219 (1.142-4.31)	0.0187	1.734 (0.853-3.526)¹/1.816 (0.907-3.636)²	0.1283¹/0.0918²
Mother’s status
HBsAg+	0.828 (0.407-1.684)	0.6021	0.766 (0.361-1.623)¹/0.763 (0.360-1.619)²	0.4862¹/0.4814²
Unknown	0.537 (0.275-1.045)	0.0673	0.549 (0.272-1.107)¹/0.559 (0.278-1.125)²	0.094¹/0.1030²
AUC (95%CI)	0.674 (0.614-0.734)	< 0.0001
	Genetic model
rs477515	2.246 (1.164-4.333)	0.0159	2.242 (1.113-4.515)	0.0238
rs9272105	1.386 (0.965-1.991)	0.0775	1.266 (0.866-1.849)	0.2232
rs7756516	1.385 (0.765-2.509)	0.2826	1.379 (0.753-2.524)	0.2977
AUC (95%CI)	0.638 (0.579-0.698)	< 0.0001	0.705 (0.648-0.763)	< 0.0001
WGRS	1.644 (1.317-2.052)	< 0.0001	1.567 (1.250-1.965)	< 0.0001
AUC (95%CI)	0.632 (0.573-0.692)	< 0.0001	0.704 (0.646-0.761)	< 0.0001
IDI (95%CI)			0.042 (0.019-0.065)	0.0003
NRI (95%CI)			0.440 (0.236-0.644)	< 0.0001

¹Each single nucleotide polymorphism was added in the mixed model.

²The weighted genetic risk score was added in the mixed model. AUC: Area under the receiver operating characteristic curve; GEE: Generalized estimating equation; IDI: Integrated discrimination improvement; NRI: Net reclassification improvement; CI: Confidence interval; HBsAg: Hepatitis B surface antigen; OR: Odds ratio.

Citation: Hsieh AR, Fann CSJ, Lin HC, Tai J, Hsieh SY, Tai DI. Hepatitis B virus persistent infection-related single nucleotide polymorphisms in HLA regions are associated with viral load in hepatoma families. World J Gastroenterol 2021; 27(37): 6262-6276
URL: https://www.wjgnet.com/1007-9327/full/v27/i37/6262.htm
DOI: https://dx.doi.org/10.3748/wjg.v27.i37.6262