Brain-gut-liver interactions across the spectrum of insulin resistance in metabolic fatty liver disease

Figure 4 Threesome ballooning hallmark of progressive fatty liver disease. Liver steatosis is associated with cardiovascular, digestive, metabolic, neoplastic, and neurodegenerative diseases; but it is the concomitant presence of inflammation that markedly accelerates the progression of these diseases. We illustrate this concept, representing steatosis as a “pedal” on which a series of aggravating factors may press as a “foot” that pushes on the “throttle”, namely inflammation.