Serum vitamin D and vitamin-D-binding protein levels in children with chronic hepatitis B

Table 3 Univariate and multivariate analyses of hepatic fibrosis in children with chronic hepatitis B

Factor	Without hepatic fibrosis, n = 27	Hepatic fibrosis, n = 97	Univariate analysis		Multivariate analysis
			Z/t/χ2 value1	P value1	OR (95%CI)1	P value1
Age in mo	54.00 (32.0-98.0)	63.00 (40.00-95.00)	0.83	0.407
Male/female	18/9	63/34	0.03	0.868
ALT in IU/L	32.03 (16.40-57.0)	43.48 (20.15-88.64)	0.98	0.330
AST in IU/L	39.11 (27.50-65.30)	47.30 (30.65-83.10)	1.14	0.254
TBil in μmoL/L	6.77 (6.10-8.80)	9.20 (6.98-14.20)	2.86	0.004	1.053 (0.938-1.182)	0.384
ALB in g/L	42.98 ± 2.17	42.30 ± 3.27	1.27	0.209
PT in s	13.29 ± 0.76	13.26 ± 0.78	0.18	0.860
25(OH)D, nmoL/L	61.86 ± 13.63	51.22 ± 14.67	3.38	0.001	0.951 (0.918-0.985)	0.005
VDBP, μg/L	90.00 (61.20-121.45)	134.50 (71.25-267.18)	1.98	0.047	1.001 (0.999-1.003)	0.316
Calcium, mmoL/L	2.30 ± 0.16	2.27 ± 0.15	0.88	0.383
Phosphorus, mmoL/L	1.48 ± 0.12	1.45 ± 0.12	1.19	0.237
HBV DNA in log10 IU/mL	5.40 (2.00-7.31)	6.88 (5.53-7.64)	2.40	0.017	1.445 (1.163-1.794)	0.001
HBeAg positive/negative	26/1	73/24	5.81	0.016	0.138 (0.017-1.160)	0.068

¹Normal distribution measurement data, non-normal distribution measurement data and numerical data were analyzed by t test, Mann-Whitney U test and χ² test to determine the difference between two groups, respectively. Binary multivariate logistic regression analysis was applied to further analyze the statistically significant factors determined by univariate analysis. 25(OH)D: 25-hydroxy vitamin D; ALB: Albumin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; CI: Confidence interval; DNA: Deoxyribonucleic acid; HBeAg: Hepatitis B e antigen; HBV: Hepatitis B virus; OR: Odds ratio; PT: Prothrombin time; TBil: Total bilirubin; VDBP: Vitamin-D-binding protein.