Serum vitamin D and vitamin-D-binding protein levels in children with chronic hepatitis B

Table 1 Serum levels of 25-hydroxy vitamin D and vitamin-D-binding protein in patients with chronic hepatitis B and healthy controls

Factor	CHB, n = 204	Healthy controls, n = 170	χ2/Z/t value1	P value1
Sex, M/F	133/71	108/62	0.11	0.737
Age in mo	61.00 (37.0-97.75)	56.00 (32.75-82.25)	1.27	0.205
ALT in IU/L	30.22 (17.80-63.36)	15.00 (8.75-24.25)	9.37	< 0.001
AST in IU/L	38.25 (28.70-64.98)	25.00 (17.00-31.50)	10.44	< 0.001
TBil in μmoL/L	8.67 (6.61-12.65)	7.00 (5.60-9.25)	4.57	< 0.001
ALB in g/L	42.52 ± 3.53	42.10 ± 5.39	0.88	0.383
PT in s	13.34 ± 0.80	11.37 ± 0.91	22.22	< 0.001
25(OH)D, nmoL/L	56.64 ± 17.89	75.48 ± 28.28	7.52	< 0.001
VDBP, μg/L	122.40 (70.74-262.84)	643.25 (415.74-1034.43)	14.89	< 0.001
Calcium, mmoL/L	2.24 ± 0.15	2.44 ± 0.16	11.99	< 0.001
Phosphorus, mmoL/L	1.47 ± 0.12	1.69 ± 0.16	14.80	< 0.001

¹Normal distribution measurement data were expressed as mean ± SD and analyzed by the t test to determine the difference between two groups. Non-normal distribution measurement data were expressed as median (interquartile range) and analyzed by Mann-Whitney U test to determine the difference between two groups. Numerical data were expressed as rate and analyzed by χ² test. 25(OH)D: 25-hydroxy vitamin D; ALB: Albumin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; F: Female; M: Male; PT: Prothrombin time; TBil: Total bilirubin; VDBP: Vitamin-D-binding protein.