Hepatocellular carcinoma in viral and autoimmune liver diseases: Role of CD4+ CD25+ Foxp3+ regulatory T cells in the immune microenvironment

Table 1 Regulatory T cell function and recruitment in hepatocellular carcinoma

Treg function in HCC		Ref.
Molecule	Target
IL-10	IL-10R	Marra and Tacke[90]
IL-35	IL-12Rβ2	Shen et al[91]
TGF-β	TGF-βR	Fu et al[92]
CTLA-4	CD80/CD86	Chen et al[93]
CD39-CD73	ATP	Chen et al[94]
IL-2 Rα (CD 25)	IL-2	Li et al[95]
LAG3	MHC class IImolecules	Cabrera et al[96]
Treg recruitment in HCC		Ref.
Molecule	Receptor
CCL22	CCR4	Li et al[97]
CCL5	CCR5	Cheng et al[98]
CCL28	CCR3, CCR10	Singh et al[99]

CTLA-4: Cytotoxic T lymphocyte-associated antigen 4; LAG3: Lymphocyte activation gene 3 protein; IL: Interleukin; TGF-β: Transforming growth factor β; Treg: Regulatory T cell; HCC: Hepatocellular carcinoma.