Neurological manifestations of hepatitis E virus infection: An overview

Table 1 Hepatitis E virus: Epidemiological features

Genotype	Hosts/reservoir	Mode of transmission	Geographic distribution	Remarks	Reported neurological manifestations1
GT1	Only humans	Fecal-oral transmission	Mostly Asia and Africa	Large outbreaks; Self-limiting; High mortality in pregnancy	Yes (2 cases)
GT2	Only humans	Fecal-oral transmission	Africa and Mexico	Large outbreaks; Self-limiting; High mortality in pregnancy	None
GT3	Human, swine, wild boar, goat, cattle, deer, camel and yak	Zoonotic infections in humans; Blood transfusion	Worldwide including Europe and America	Can cause chronic infection in organ transplant patients	Yes (56 cases)
GT4	Human, swine, wild boar, goat, cattle, deer, camel and yak	Zoonotic infections in humans; Blood transfusion	China, Japan, South-east Asia	Can cause chronic infection in organ transplant patients	Yes (4 cases)

¹See Table 3 for reported neurological manifestations. GT: Genotype.