Effects of CXCL12 isoforms in a pancreatic pre-tumour cellular model: Microarray analysis

Table 1 List of differentially expressed genes upon treatment of pancreatic hTERT-HPNE cells with 3 different isoforms of CXCL12

Probe name	Log2FC	P value	Adjusted P value	Gene name
CXCL12 α isoform vs control
TC1100012755.hg.1	-1.203589	3.12 × 10-8	0.000052	KIRREL3
TC1700010680.hg.1	-1.036293	1.56 × 10-6	0.001479	KRT14
TC0200015894.hg.1	-1.009543	1.37 × 10-6	0.001358	DOCK10
TC1700007330.hg.1	-0.937268	9.64 × 10-6	0.007801	KSR1
TC0200007399.hg.1	-0.920275	1.26 × 10-5	0.009220	PLEKHH2
TC1000011549.hg.1	-0.908378	2.40 × 10-5	0.016397	RRP12
TC1100009990.hg.1	-0.841133	5.45 × 10-5	0.032188	OR6A2
TC1000011923.hg.1	-0.827117	7.17 × 10-5	0.038532	GFRA1
TC0300013528.hg.1	-0.824444	7.59 × 10-5	0.038532	GMNC
TC1800009242.hg.1	-0.818366	1.03 × 10-4	0.049741	SERPINB2
TC0300007393.hg.1	0.807450	1.12 × 10-4	0.049980	UBA7
TSUnmapped00000150.hg.1	0.812168	1.05 × 10-4	0.049741	OBP2B
TC0400008134.hg.1	0.841986	5.91 × 10-5	0.033939	MMRN1
TC1300010008.hg.1	0.854761	4.73 × 10-5	0.028684	GAS6-AS1
TC0100008815.hg.1	0.864724	1.12 × 10-4	0.049980	IFI44L
TC1600010467.hg.1	0.873123	2.89 × 10-5	0.019144	CNGB1
TC0400011618.hg.1	0.958292	5.08 × 10-6	0.004269	NEUROG2
CXCL12 β isoform vs control
TC0400007836.hg.1	-1.317647	3.40 × 10-9	0.000008	CXCL8
TC0400011408.hg.1	-1.007967	2.72 × 10-6	0.002057	ADH1B
TC2100006784.hg.1	-1.000559	9.12 × 10-7	0.000839	JAM2
TSUnmapped00000478.hg.1	-0.944922	2.60 × 10-6	0.002052	ZNF502
TC0400006661.hg.1	-0.799480	1.01 × 10-4	0.033702	STK32B
TC0200014802.hg.1	-0.797931	7.39 × 10-5	0.028291	SCN3A
TC1000011549.hg.1	-0.796631	8.77 × 10-5	0.030275	RRP12
TC0200015894.hg.1	-0.792474	9.80 × 10-5	0.033299	DOCK10
TC0X00010399.hg.1	-0.779084	1.41 × 10-4	0.042386	BEX1
TC0600014250.hg.1	-0.776865	1.08 × 10-4	0.034696	ZBED9
TC0300007220.hg.1	-0.767719	1.30 × 10-4	0.040552	ZNF502
TC0400009879.hg.1	-0.764228	1.70 × 10-4	0.049472	CYTL1
TC0600013231.hg.1	0.768484	1.61 × 10-4	0.047319	SGK1
TC1300007248.hg.1	0.803510	8.35 × 10-5	0.029556	CKAP2
TC1100013221.hg.1	0.818187	4.63 × 10-5	0.019311	CASP1
TC0500012030.hg.1	0.819484	4.61 × 10-5	0.019311	GDF9
TC0300007393.hg.1	0.838000	3.14 × 10-5	0.014151	UBA7
TC0300012670.hg.1	0.853540	2.67 × 10-5	0.012705	ATR
TC0100013700.hg.1	0.868308	2.28 × 10-5	0.011426	CLSPN
TC0600007138.hg.1	0.884415	1.49 × 10-5	0.008040	E2F3
TC0600010241.hg.1	0.895254	9.02 × 10-6	0.005389	KIF25
TC0100008101.hg.1	0.951395	3.50 × 10-6	0.002479	KIF2C
TC0500010150.hg.1	1.068352	1.53 × 10-7	0.000178	DNAH5
TC0500011752.hg.1	1.070992	1.39 × 10-7	0.000171	FEM1C
CXCL12 γ isoform vs control
TC1700010680.hg.1	-1.080970	5.93 × 10-8	0.000105	KRT14
TC0400011408.hg.1	-0.986416	1.69 × 10-5	0.011437	ADH1B
TC0200015894.hg.1	-0.932303	1.47 × 10-6	0.001696	DOCK10
TC0400007836.hg.1	-0.928065	6.86 × 10-6	0.005275	CXCL8
TC0400006661.hg.1	-0.899192	5.58 × 10-6	0.004432	STK32B
TC2100006784.hg.1	-0.897234	3.99 × 10-6	0.003542	JAM2
TC1000011549.hg.1	-0.840455	1.83 × 10-5	0.012077	GFRA1
TC1100012755.hg.1	-0.836071	2.44 × 10-5	0.015179	KIRREL3
TC1200008176.hg.1	-0.818598	6.33 × 10-5	0.032429	LGR5
TC1700007330.hg.1	-0.815796	2.93 × 10-5	0.017802	KSR1
TSUnmapped00000478.hg.1	-0.787902	4.44 × 10-5	0.025573	ZNF502
TC1100009990.hg.1	-0.785292	4.90 × 10-5	0.027540	OR6A2
TC0600014250.hg.1	-0.774330	6.12 × 10-5	0.032045	ZBED9
TC0X00010399.hg.1	-0.769031	1.00 × 10-4	0.047072	BEX1
TC0500011752.hg.1	0.893861	4.79 × 10-6	0.004094	FEM1C
TC1100013221.hg.1	0.922373	2.14 × 10-6	0.002246	CASP1

Only significant differentially expressed genes are reported (adjusted P values < 0.05). FC: Fold change.