Apolipoprotein E polymorphism influences orthotopic liver transplantation outcomes in patients with hepatitis C virus-induced liver cirrhosis

Table 3 METAVIR scores for liver inflammation in pre-orthotopic liver transplantation patients according to E2, E3 and E4 alleles stratification

METAVIR score	APOE2			APOE3			APOE4
	Yes	No		Yes	No		Yes	No
	n2 (%)	n2 (%)	P value	n2 (%)	n2 (%)	P value	n2 (%)	n2 (%)	P value
METAVIR (n1 = 38; n2 = 76)
A1F4 (n1 = 27; n2 = 54)	13 (24.1)	41 (75.9)	0.764	31 (57.4)3	23 (42.6)	0.064	10 (18.5)	44 (81.5)	0.055
A3F4 (n1 = 11; n2 = 22)	4 (18.2)	18 (81.8)		18 (81.8)	4 (18.2)		0 (0.0)1	22 (100.0)
METAVIR (n1 = 91; n2 = 182)
≤ A2F4 (n1 = 80; n2 = 160)	31 (19.4)	129 (80.6)	1.000	103 (64.4)4	57 (35.6)	0.148	26 (16.2)	134 (83.8)	0.048a
A3F4 (n1 = 11; n2 = 22)	4 (18.2)	18 (81.8)		18 (81.8)	4 (18.2)		0 (0.0)2	22 (100.0)

n¹: Number of subjects; n²: Number of alleles.

³APOE3 vs APOE4 allele frequency, P = 0.024.

⁴APOE3 vs APOE4 allele frequency, P = 0.043.

^aP < 0.05. METAVIR A1: Minimal degree of inflammation; METAVIR A1A2: Minimal and moderate degree of inflammation; METAVIR A3: High degree of inflammation; APOE: Apolipoprotein E gene.