Clinical features of multiple gastrointestinal stromal tumors: A pooling analysis combined with evidence and gap map

Table 1 Baseline characteristics of patients with multiple gastrointestinal stromal tumors, n (%)

	PKUPH patients, n = 121	Literature-based patients, n = 1611	Total patients, n = 1731
Sex	n = 12	n = 160	n = 172
Female	6 (50.00)	96 (60.00)	102 (59.30)
F/M	1.00	1.48	1.46
Age in yr	n = 12	n = 161	n = 173
Range	53-88	8-84	8-88
≤ 20	0 (0.00)	25 (15.63)	25 (14.45)
21-40	0 (0.00)	29 (18.12)	29 (16.86)
41-60	2 (16.67)	51 (31.88)	53 (30.81)
61-80	9 (75.00)	51 (31.88)	60 (34.88)
> 80	1 (8.33)	5 (3.13)	6 (3.49)
Mean (SD)	65.33 (9.48)	48.70 (21.17)	49.85 (20.99)
Symptoms	n = 12	n = 55	n = 67
GI bleeding	2 (16.67)	31 (56.36)	33 (49.25)
Hematochezia	1 (8.33)	13 (24.07)	14 (21.21)
Anemia	0 (0.00)	11 (20.37)	11 (16.67)
Hematemesis	1 (8.33)	2 (3.70)	3 (4.55)
Incidental finding	7 (58.33)	15 (27.27)	22 (32.83)
Abdominal pain	2 (16.67)	14 (25.45)	16 (23.88)
Palpable mass	0 (0.00)	2 (3.64)	2 (2.99)
Others	1 (8.33)	11 (20.00)	12 (17.91)
Classification	n = 12	n = 161	n = 173
Sporadic multiple GIST	10 (83.33)	53 (32.92)	63 (36.42)
NF-1 associated GIST	2 (16.67)	72 (44.72)	74 (42.77)
Primary familial GIST	0 (0.00)	8 (4.97)	8 (4.62)
Pediatric GIST	0 (0.00)	25 (15.53)	25 (14.45)
Carney-Stratakis syndrome	0 (0.00)	0 (0.00)	0 (0.00)
Carney triads	0 (0.00)	3 (1.86)	3 (1.73)
Combined diseases	n = 12	n = 161	n = 173
GI tumors	0 (0.00)	3 (1.86)	3 (1.73)
GU tumors	0 (0.00)	5 (3.11)	5 (2.89)
Breast tumors	1 (8.33)	7 (4.35)	8 (4.62)
Other tumors	0 (0.00)	5 (3.11)	5 (2.89)

¹n For total number of patients, other n for number of patients with relevant data. GI: Gastrointestinal; GIST: Gastrointestinal stromal tumor; GU: Genitourinary tract; PKUPH: Peking University People’s Hospital; SD: Standard deviation.