Retrospective Study
Copyright ©The Author(s) 2020.
World J Gastroenterol. Dec 14, 2020; 26(46): 7382-7404
Published online Dec 14, 2020. doi: 10.3748/wjg.v26.i46.7382
Table 2 Correlation between preoperative plasma fibrinogen concentration and clinicopathological characteristics in pancreatic ductal adenocarcinoma patients who underwent R0 resection, n (%)
Characteristics
Preoperative plasma fibrinogen concentration
P value
> 3.31 g/L, n = 141
≤ 3.31 g/L, n = 141
Age in yr0.812
> 6072 (25.5)74 (26.2)
≤ 6069 (24.5)67 (23.8)
Sex0.283
Male71 (25.2)80 (28.4)
Female70 (24.8)61 (21.6)
Clinical symptoms< 0.001
Absent15 (5.3)42 (14.9)
Present126 (44.7)99 (35.1)
Diabetes0.357
Absent97 (34.4)104 (36.9)
Present44 (15.6)37 (13.1)
Smoking status0.889
Absent107 (37.9)108 (38.3)
Present34 (12.1)33 (11.7)
Alcohol consumption0.263
Absent121 (42.9)114 (40.4)
Present20 (7.1)27 (9.6)
Family history of cancer0.356
Absent137 (48.6)134 (47.5)
Present4 (1.4)7 (2.5)
Blood type0.565
A39 (13.8)48 (17.0)
B51 (18.1)42 (14.9)
AB10 (3.5)12 (4.3)
O41 (14.5)39 (13.8)
Tumor location< 0.001
Head and neck80 (28.4)50 (17.7)
Body and tail61 (21.6)91 (32.3)
Approaches of open surgery< 0.001
Pancreaticoduodenectomy80 (28.4)50 (17.7)
Distal pancreatectomy with splenectomy61 (21.6)91 (32.3)
Degree of differentiation0.079
Well20 (7.1)14 (5.0)
Moderately111 (39.4)106 (37.6)
Poorly10 (3.5)21 (7.4)
Lymphovascular invasion0.233
Absent97 (34.4)106 (37.6)
Present44 (15.6)35 (12.4)
Perineural invasion0.054
Absent28 (9.9)42 (14.9)
Present113 (40.1)99 (35.1)
Capsular invasion0.271
Absent21 (7.4)28 (9.9)
Present120 (42.6)113 (40.1)
Maximum tumor diameter in cm1.000
> 444 (15.6)44 (15.6)
≤ 497 (34.4)97 (34.4)
T stage0.991
T117 (6.0)17 (6.0)
T280 (28.4)79 (28.0)
T344 (15.6)45 (16.0)
Number of metastatic lymph nodes0.718
Absent82 (29.1)79 (28.0)
Present59 (20.9)62 (22.0)
N stage0.110
N082 (29.1)79 (28.0)
N140 (14.2)52 (18.4)
N219 (6.7)10 (3.5)
TNM stage0.099
IA8 (2.8)12 (4.3)
IB44 (15.6)48 (17.0)
IIA30 (10.6)19 (6.7)
IIB40 (14.2)52 (18.4)
III19 (6.7)10 (3.5)
Adjuvant therapy0.631
Absent64 (22.7)60 (21.3)
Present77 (27.3)81 (28.7)
Preoperative CA19-9 level in U/mL0.023
> 336.447 (16.7)30 (10.6)
≤ 336.494 (33.3)111 (39.4)
Preoperative plasma albumin level in g/L0.006
> 45.232 (11.3)53 (18.8)
≤ 45.2109 (38.2)88 (31.2)
Preoperative FAR< 0.001
> 0.08114 (40.4)12 (4.3)
≤ 0.0827 (9.6)129 (45.7)