Discovery of unique African Helicobacter pylori CagA-multimerization motif in the Dominican Republic

doi:10.3748/wjg.v26.i45.7118

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 7, 2020; 26(45): 7118-7130
Published online Dec 7, 2020. doi: 10.3748/wjg.v26.i45.7118

Table 2 Peptide sequences and types of CagA-multimerization motif in Helicobacter pylori strains

First motif			Second motif			Third motif
Peptide sequences	Type	No.	Peptide sequences	Type	No.	Peptide sequences	Type	No.
FPLKRHDKVDDLSKVG	W-CM	45	FPLKRHDKVDDLSKVG	W-CM	31	FPLKRHDKVDDLSKVG	W-CM	4
FPLKRHDKVEDLSKVG	W-CM	17	FPLRRSAKVEDLSKVG	Af1-CM	21	FPLRRSAKVEDLSKVG	Af1-CM	2
FPLKRHAKVDDLSKVG	W-CM	4	FPLKKHAKVEDLSKVG	D-CM	7	FLLKRHDKVDDLSKVG	W-CM	1
FPLKKHAKVEDLSKVG	D-CM	3	FPLRRSAKVEDLSKAG	Af1-CM	4
FPLKKHDKVDDLSKVG	W-CM	3	FPLKKHDKVEDLSKVG	W-CM	2
FPLKKHDKVEDLSKVG	W-CM	3	FPLKRSAKVEDLSKVG	Af1-CM	2
FPLKKHAKVDDLSKVG	W-CM	2	FPLKRSAKVDDLSKVG	D-CM	2
FLLKRHDKVDNLSKVG	W-CM	1	FPLRRSAKVDDLSKVG	Af1-CM	2
FPLRRSDKVDDLSKVG	D-CM	1	FPLKRYDKVDNLSKVG	W-CM	2
FPLKKHAKVEDLSEVG	D-CM	1	FPLKRHDKVEDLSKVG	W-CM	1
FPLKRHDKIDDLSKVG	W-CM	1	FPLKKHDKVDDLSKVG	W-CM	1
FPLKKHAKVEDLSKAG	D-CM	1	FPLRRSTKVEDLSKAG	Af1-CM	1
Nothing (Deletion)		2	FPLRRSAAVDDLSKVG	E-CM	1
			FPLRRGAKVEDLSKVG	Af1-CM	1
			FPLRKSAKVEDLSKVG	Af1-CM	1
			FPLRRSDKVDNLSKVG	D-CM	1
			FPSKKHAKVEDLSKVG	D-CM	1
			FPFRRSDKVEDLSKVG	Af1-CM	1
			FPLRRSDKVEDLSKVG	Af1-CM	1
Total		84	Total		83	Total		7

The CagA-multimerization (CM) motif types were determined based on comparison with the typical Western CM motif (FPLKRHDKVDDLSKVG), the typical East Asian CM motif (FPLRRSAAVNDLSKVG), and the typical Africa1 CM motif (FPLRRSAKVEDLSKVG). W-CM: Western CM motif; E-CM: East-Asian CM motif; Af1-CM: Africa1-CM motif; D-CM: Different CM motif.

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Citation: Ono T, Cruz M, Nagashima H, Subsomwong P, Akada J, Matsumoto T, Uchida T, Suzuki R, Hosking C, Jiménez Abreu JA, Yamaoka Y. Discovery of unique African Helicobacter pylori CagA-multimerization motif in the Dominican Republic. World J Gastroenterol 2020; 26(45): 7118-7130
URL: https://www.wjgnet.com/1007-9327/full/v26/i45/7118.htm
DOI: https://dx.doi.org/10.3748/wjg.v26.i45.7118

Ono T, Cruz M, Nagashima H, Subsomwong P, Akada J, Matsumoto T, Uchida T, Suzuki R, Hosking C, Jiménez Abreu JA, Yamaoka Y. Discovery of unique African Helicobacter pylori CagA-multimerization motif in the Dominican Republic. World J Gastroenterol 2020; 26(45): 7118-7130 [PMID: 33362372 DOI: 10.3748/wjg.v26.i45.7118]

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