Discovery of unique African Helicobacter pylori CagA-multimerization motif in the Dominican Republic

doi:10.3748/wjg.v26.i45.7118

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Dec 7, 2020; 26(45): 7118-7130
Published online Dec 7, 2020. doi: 10.3748/wjg.v26.i45.7118

Table 2 Peptide sequences and types of CagA-multimerization motif in Helicobacter pylori strains

First motif			Second motif			Third motif
Peptide sequences	Type	No.	Peptide sequences	Type	No.	Peptide sequences	Type	No.
FPLKRHDKVDDLSKVG	W-CM	45	FPLKRHDKVDDLSKVG	W-CM	31	FPLKRHDKVDDLSKVG	W-CM	4
FPLKRHDKVEDLSKVG	W-CM	17	FPLRRSAKVEDLSKVG	Af1-CM	21	FPLRRSAKVEDLSKVG	Af1-CM	2
FPLKRHAKVDDLSKVG	W-CM	4	FPLKKHAKVEDLSKVG	D-CM	7	FLLKRHDKVDDLSKVG	W-CM	1
FPLKKHAKVEDLSKVG	D-CM	3	FPLRRSAKVEDLSKAG	Af1-CM	4
FPLKKHDKVDDLSKVG	W-CM	3	FPLKKHDKVEDLSKVG	W-CM	2
FPLKKHDKVEDLSKVG	W-CM	3	FPLKRSAKVEDLSKVG	Af1-CM	2
FPLKKHAKVDDLSKVG	W-CM	2	FPLKRSAKVDDLSKVG	D-CM	2
FLLKRHDKVDNLSKVG	W-CM	1	FPLRRSAKVDDLSKVG	Af1-CM	2
FPLRRSDKVDDLSKVG	D-CM	1	FPLKRYDKVDNLSKVG	W-CM	2
FPLKKHAKVEDLSEVG	D-CM	1	FPLKRHDKVEDLSKVG	W-CM	1
FPLKRHDKIDDLSKVG	W-CM	1	FPLKKHDKVDDLSKVG	W-CM	1
FPLKKHAKVEDLSKAG	D-CM	1	FPLRRSTKVEDLSKAG	Af1-CM	1
Nothing (Deletion)		2	FPLRRSAAVDDLSKVG	E-CM	1
			FPLRRGAKVEDLSKVG	Af1-CM	1
			FPLRKSAKVEDLSKVG	Af1-CM	1
			FPLRRSDKVDNLSKVG	D-CM	1
			FPSKKHAKVEDLSKVG	D-CM	1
			FPFRRSDKVEDLSKVG	Af1-CM	1
			FPLRRSDKVEDLSKVG	Af1-CM	1
Total		84	Total		83	Total		7

The CagA-multimerization (CM) motif types were determined based on comparison with the typical Western CM motif (FPLKRHDKVDDLSKVG), the typical East Asian CM motif (FPLRRSAAVNDLSKVG), and the typical Africa1 CM motif (FPLRRSAKVEDLSKVG). W-CM: Western CM motif; E-CM: East-Asian CM motif; Af1-CM: Africa1-CM motif; D-CM: Different CM motif.

Citation: Ono T, Cruz M, Nagashima H, Subsomwong P, Akada J, Matsumoto T, Uchida T, Suzuki R, Hosking C, Jiménez Abreu JA, Yamaoka Y. Discovery of unique African Helicobacter pylori CagA-multimerization motif in the Dominican Republic. World J Gastroenterol 2020; 26(45): 7118-7130
URL: https://www.wjgnet.com/1007-9327/full/v26/i45/7118.htm
DOI: https://dx.doi.org/10.3748/wjg.v26.i45.7118