Prognostic value of changes in serum carcinoembryonic antigen levels for preoperative chemoradiotherapy response in locally advanced rectal cancer

Table 6 Multivariate analysis for prognostic markers to predict the response to the chemoradiotherapy

	Pathologic complete response		Good response (TRG 0,1)
	OR (95%CI)	P value	OR (95%CI)	P value
Sex (female vs male)	0.26 (0.08–0.80)	0.022
Pre-CRT CEA (> 5 vs ≤ 5 ng/mL)	18.71 (4.62–129.51)	< 0.001
Pre-CRT NLR (≥ 2.8 vs < 2.8)	5.27 (1.55–22.55)	0.013	2.82 (1.27–6.48)	0.013
Post-CRT CEA (> 5 vs ≤ 5 ng/mL)			5.07 (1.92–14.83)	0.002
Post-CRT T stage (≥ T3 vs < T3)	3.25 (1.09–9.97)	0.036	3.28 (1.23–9.90)	0.023
Postop differentiation (poorly1vs well-mod.)			3.41 (1.35–9.48)	0.013

¹Mucinous, signet ring cell, OR: Odds ratio; CI: Confidence interval; TRG: Tumor regression grade; CRT: Chemoradiotherapy; CEA: Carcinoembryonic antigen; NLR: Neutrophil–lymphocyte ratio.