Prognostic value of changes in serum carcinoembryonic antigen levels for preoperative chemoradiotherapy response in locally advanced rectal cancer

Table 2 Patient characteristics

Characteristics	Distribution
Age (yr, mean ± SD)	60.1 ± 10.9
Sex
Male	99 (73.3%)
Female	36 (26.7%)
BMI (kg/m2, mean ± SD)	22.9 ± 3.1
Smoker	46 (34.1%)
ASA
1	80 (59.3%)
2	40 (29.6%)
3	14 (10.4%)
4	1 (0.7%)
Distance of tumor from the anal verge (cm, mean ± SD)	6.4 ± 3.0
Pre-CRT CEA (ng/mL, mean ± SD)	18.1 ± 45.0
Pre-CRT tumor size (cm, mean ± SD)	4.6 ± 1.4
Pre-CRT TNM stage
I	1 (0.7%)
II	13 (9.6%)
III	121 (89.6%)
Curative resection after CRT
Low anterior resection	64 (47.4%)
Ultra-low anterior resection	17 (12.6%)
Abdominoperineal resection	46 (34.1%)
Hartmann operation	7 (5.2%)
Total colectomy	1 (0.7%)
Radiation dose, cGy	5040
Interval from preoperative CRT to operation (wk)	7.8 ± 1.7
Post-CRT CEA (ng/mL)	4.8 ± 8.1
Down-staging after preoperative CRT	60 (44.4%)
Pathologic complete response	27 (20.0%)
Adjuvant chemotherapy	121 (89.6%)
Follow-up (mo)	60.4 ± 24.3

SD: Standard deviation; BMI: Body mass index; ASA: American Society of Anesthesiology; CEA: Carcinoembryonic antigen; TNM: Tumor Node Metastasis; CRT: Chemoradiotherapy. I