Dynamic contrast-enhanced magnetic resonance imaging and diffusion-weighted imaging in the activity staging of terminal ileum Crohn's disease

Figure 1 A 41-year-old male with moderate active Crohn’s disease in the terminal ileum and a Crohn’s Disease Activity Index of 267 and Crohn’s Disease Endoscopic Index of Severity of 12. A: Terminal ileum demonstrates wall thickening and increased signal on axial T2-weighted image; B: Terminal ileum wall has a high signal. Axial diffusion-weighted imaging image (b = 800 s/mm²) demonstrates high signal (arrow) in the same bowel segment. Region of interest (ROI) for the inflammatory bowel wall shows that apparent diffusion coefficient = 1.11×10^-3 mm²/s; C: ROI for the inflammatory bowel wall shows that K^trans = 0.10 min^-1 (K_ep = 0.87 min^-1, V_e = 0.11); D: In contrast, ROI of the normal appearing ileal loop shows that K^trans = 0.01 min^-1 (K_ep = 0.80 min^-1, V_e = 0.02); E: The contrast concentration curve of inflammatory bowel is plotted as ROI (line with circle) and fitted with the model (line); F: The contrast concentration curve of normal loop is plotted as ROI (line with circle) and fitted with the model (line). ROI: Region of interest.