Epidemiology of perforating peptic ulcer: A population-based retrospective study over 40 years

Table 3 Trends in treatment and outcome according to decade of treatment, n (%)

n = 209	1978–1987 (n = 38)	1988–1997 (n = 64)	1998–2007 (n = 62)	2008-2017 (n = 45)	P value
Treatment
Simple closure with orwithout omentopexy	37 (97)	64 (100)	62 (100)	38 (84)
Gastric resection	1 (3)	0	0	4 (9)
No operation	0	0	0	3 (7)
Hours from admission to operation, mean ± SD	7 ± 9	8 ± 12	16 ± 29	13 ± 14	0.019a
Duration of operation, mean ± SD, min	72 ± 29	78 ± 35	61 ± 24	78 ± 40	0.15a
Re-operation	1 (3)	4 (6)	6 (10)	4 (9)	0.18b
Clavien-Dindo classification of complications
0	28 (74)	45 (70)	38 (61)	17 (38)	0.001c
1-2	6 (16)	8 (13)	9 (15)	13 (29)
3	1 (3)	1 (29)	4 (7)	4 (9)
4	0	4 (6)	3 (5)	3 (7)
5	3 (8)	6 (9)	8 (13)	8 (18)
100-day mortality	7 (18)	11 (17)	16 (26)	9 (20)	0.56b
Estimated 10-yr relative survival in patients surviving 100 d, (95%CI)	97 (70-114)	71 (52-87)	86 (64-103)	86 (51-108)	0.44d

^aJonckheere-Terpstra exact test.

^bCochran-Armitage exact trend test.

^cOrdered logistic regression analysis.

^dRelative survival analysis with calendar period as covariate. SD: Standard deviation; CI: Confidence interval.