Copyright
©The Author(s) 2020.
World J Gastroenterol. Jan 21, 2020; 26(3): 324-334
Published online Jan 21, 2020. doi: 10.3748/wjg.v26.i3.324
Published online Jan 21, 2020. doi: 10.3748/wjg.v26.i3.324
Table 1 Patient baseline characteristics: Clinical and biological characteristics, portal hypertension evidence, and anthropometric analyses, n (%)
| Characteristics | Doxorubicin, n = 60 | Idarubicin, n = 30 |
| Clinical and biological data | ||
| Sex, male/female | 54 (90.0)/6 (10.0) | 28 (93.3)/2 (6.7) |
| Age in yr, mean ± SD | 62.9 ± 9.0 | 61.9 ± 9.8 |
| WHO performance status 0/1 | 51 (85.0)/9 (15.0) | 25 (83.3)/5 (16.6) |
| BMI, median (IQR) | 27.6 (24.7-32.1) | 25.2 (22.9-27.2) |
| < 20 | 2 (3.3) | 2 (6.9) |
| 20-24.9 | 15 (25.0) | 12 (41.4) |
| ≥ 25 | 43 (71.7) | 15 (51.7) |
| Tumor characteristics | ||
| Tumor number, median (IQR) | 2 (1-3) | 2 (2-3.75) |
| 1 nodule | 17 (28.3) | 7 (23.3) |
| 2-3 nodules | 31 (51.7) | 15 (50.0) |
| > 3 nodules | 12 (20.0) | 8 (26.7) |
| 2 largest nodules sum in mm, median (IQR) | 49.5 (32.8-62.0) | 40.5 (30.5-58.8) |
| Partial portal vein thrombosis | 8 (13) | 3 (10) |
| Underlying cirrhosis | ||
| Yes/no | 56 (93.3)/4 (6.7) | 26 (86.7)/4 (13.3) |
| Child-Pugh class A/B | 52 (86.7)/8 (13.3) | 21 (70.0)/9 (30.0) |
| MELD, median (IQR) | 9.22 (8.13-10.57) | 8.19 (7.34-9.86) |
| Etiology | ||
| Alcohol | 18 (30.0) | 6 (20.0) |
| HBV/HCV infection | 11 (18.3) | 4 (13.3) |
| Metabolic | 7 (11.7) | 1 (3.3) |
| Alcohol + HBV/HCV | 3 (5.0) | 8 (26.7) |
| Alcohol + Metabolic | 16 (26.7) | 5 (16.7) |
| Hemochromatosis | 3 (5.0) | 2 (6.7) |
| Biological parameters | ||
| Platelet count in G/L, median (IQR) | 112.5 (82.8-171.5) | 106.5 (86.3-135.3) |
| Albumin in g/dL, median (IQR) | 3.7 (3.4-3.9) | 3.5 (3.1-3.9) |
| Total bilirubin in mg/dL, median (IQR) | 0.94 (0.58-1.18) | 0.73 (0.48-1.04) |
| AST in IU/L, median (IQR) | 46 (33-65) | 55 (34-68) |
| ALT in IU/L, median (IQR) | 44 (34-70) | 40 (29-60 |
| GGT in IU/L, median (IQR) | 152 (92-261) | 185 (141-332) |
| ALP in IU/L, median (IQR) | 105 (88-133) | 115 (88-139) |
| PT as %, median (IQR) | 79.5 (67.0-85.8) | 79.5 (63.3-89.3) |
| AFP in ng/mL, median (IQR) | 12.7 (4.6-109.3) | 16.0 (5.2-35.0) |
| Drug administration method | ||
| Conventional TACE/beads | 48 (80)/12 (20.0) | 24 (80)/6 (20.0) |
| Drug dose in mg, median (IQR) | 50 (50-50) | 10 (10-10) |
| TACE territory: Global/lobar/segmental | 34 (56.7)/20 (33.3)/6 (10.0) | 15 (50)/14(46.7)/1(3.3) |
| Portal hypertension evidence | ||
| Ascites on preoperative scan: No/yes | 49 (76.6)/15 (23.4) | 21 (65.6)/11 (34.4) |
| Splenomegaly on preoperative scan: No/yes | 27 (45.0)/33 (55.0) | 7 (23.3)/23 (76.7) |
| Esophageal varices | ||
| None | 28 (46.7) | 17 (56.7) |
| Grade 1/2/3 | 14 (23.3)/17 (28.3)/1 (1.7) | 2 (6.7)/9 (30.0)/2 (6.7) |
| Low platelet count as < 100 000/mm3: No/yes | 37 (61.6)/23 (38.3) | 18 (60.0)/12 (40.0) |
- Citation: Roth GS, Teyssier Y, Abousalihac M, Seigneurin A, Ghelfi J, Sengel C, Decaens T. Idarubicin vs doxorubicin in transarterial chemoembolization of intermediate stage hepatocellular carcinoma. World J Gastroenterol 2020; 26(3): 324-334
- URL: https://www.wjgnet.com/1007-9327/full/v26/i3/324.htm
- DOI: https://dx.doi.org/10.3748/wjg.v26.i3.324