Copyright
©The Author(s) 2020.
World J Gastroenterol. Aug 7, 2020; 26(29): 4218-4239
Published online Aug 7, 2020. doi: 10.3748/wjg.v26.i29.4218
Published online Aug 7, 2020. doi: 10.3748/wjg.v26.i29.4218
Clinicaltrials.gov identifier (NCT number) | Study type | Neoadjuvant schedule | Primary outcome | Planned enrollment | Recruitment status |
NCT03402477 | Observational | Radiotherapy or chemo-radiotherapy (at least 40 Gy) or short-course radiotherapy combined with chemotherapy | Local relapse rate | 100 | Recruiting |
Prospective | |||||
NCT03125343 | Interventional | According to the Swedish National | 3-yr disease free survival | 200 | Recruiting |
Non-randomized | Program for rectal cancer | ||||
NCT03846726 | Observational | Neoadjuvant chemoradiotherapy | Disease free survival | 513 | Active, not recruiting |
Retrospective | |||||
NCT03064646 | Interventional | Neoadjuvant chemoradiotherapy or neoadjuvant radiotherapy associated or not with induction chemotherapy | Local relapse rate | 30 | Recruiting |
Non-randomized | |||||
NCT03426397 | Observational | Short course of radiation or neoadjuvant chemoradiotherapy | 2-yr non-regrowth disease free survival | 220 | Recruiting |
Prospective | |||||
NCT04009876 | Interventional | 5-FU/LV + Oxaliplatin + nal-IRI for 8 cycles followed by standard chemoradiation (5 wk) | Clinical complete response rate | 30 | Recruiting |
Non-randomized | |||||
NCT03001362 | Interventional | 54 Gy in 30fx with radiosensitizing chemotherapy as per institutional standard | Local relapse rate | 48 | Recruiting |
Non-randomized | |||||
NCT02704520 | Interventional | Experimental arm: 45Gy-55Gy long course radiotherapy with radiosensitizing chemotherapy as per institutional standard | Feasibility phase: To assess the rate of patient recruitment | 98 | Recruiting |
Randomized | |||||
Phase III trial: 3-years disease free suvival | |||||
NCT04095299 | Interventional | Experimental arm: 62 Gy to the clinical tumor volume and 50.4 Gy to the elective volume with capecitabine | 2-yr rectal preservation | 111 | Recruiting |
Randomized |
- Citation: López-Campos F, Martín-Martín M, Fornell-Pérez R, García-Pérez JC, Die-Trill J, Fuentes-Mateos R, López-Durán S, Domínguez-Rullán J, Ferreiro R, Riquelme-Oliveira A, Hervás-Morón A, Couñago F. Watch and wait approach in rectal cancer: Current controversies and future directions. World J Gastroenterol 2020; 26(29): 4218-4239
- URL: https://www.wjgnet.com/1007-9327/full/v26/i29/4218.htm
- DOI: https://dx.doi.org/10.3748/wjg.v26.i29.4218