Retrospective Cohort Study
Copyright ©The Author(s) 2020.
World J Gastroenterol. Jul 14, 2020; 26(26): 3780-3791
Published online Jul 14, 2020. doi: 10.3748/wjg.v26.i26.3780
Table 5 Sensitivity, specificity, positive and negative predictive value of recalculated cutoff values of anti-tissue transglutaminase antibodies and anti-deamidated gliadin peptide antibodies autoantibodies titers and their combination with small bowel ultrasonography for prediction of villous atrophy in patients with celiac disease
CharacteristicsSensitivity (%) (95%CI)Specificity (%) (95%CI)Accuracy (%) (95%CI)Positive predictive value (%) (95%CI)Negative predictive value (%) (95%CI)
Autoantibodies aTTG IgA (cutoff: 13.4)66.7 (41.0-86.7)93.7 (84.5-98.2)87.7 (78.5-93.9)75.0 (52.4-89.1)90.8 (83.6-95.0)
Autoantibodies aTTG IgG (cutoff: 6.7)33.3 (13.3-59.0)87.3 (76.5-94.4)75.3 (64.5-84.2)42.9 (23.0-65.3)82.1 (76.5-86.6)
Autoantibodies aDGP IgA (cutoff: 22.6)72.2 (46.5-90.3)90.0 (79.5-96.2)85.9 (76.2-92.7)68.4 (49.1-83.0)91.5 (83.6-95.8)
Autoantibodies aDGP IgG (cutoff: 28.8)61.1 (35.8-82.7)90.0 (79.5-96.2)83.3 (73.2-90.8)64.7 (44.1-81.0)88.5 (81.1-93.3)
Autoantibodies aTTG IgA (cutoff 13.4) AND ultrasonography47.1 (23.0-72.2)98.0 (89.2-99.9)84.9 (73.9-92.5)88.9 (51.9-98.3)84.2 (77.3-89.3)
Autoantibodies aDGP IgA (cutoff 22.6) AND ultrasonography52.9 (27.8-77.0)97.8 (88.5-99.9)85.7 (74.6-93.3)90.0 (55.2-98.5)84.9 (77.2-90.3)