Role of regenerating islet-derived proteins in inflammatory bowel disease

Table 2 Effects of genetically modified REG/Reg genes on the composition of intestinal bacterial microbiota in mice

Class	Order	Family	Genera
Actinobacteria	Bifidobacteriales	Bifidobacteriaceae	Bifidobacterium ↑2
	Coriobacteriales	Coriobacteriaceae ↓1↓3
	Eggerthellales	Eggerthellaceae	Enterorhabdus ↓3
Alphaproteobacteria	Caulobacterales	Caulobacteraceae	Brevundimonas ↓3
	Rhizobiales	Bartonellaceae	Bartonella ↑3
Bacilli	Bacillales	Bacillaceae	Oceanobacillus ↑3
		Staphylococcaceae	Staphylococcus ↓2
			Lactococcus ↑3
		N/A	Gemella ↑3
	Lactobacillales ↑3	Lactobacillaceae −1	Lactobacillus ↓2↑3−4↓5
		Enterococcaceae	Enterococcus ↑2↑3
		Aerococcaceae	Facklamia ↓3
		Carnobacteriaceae	Carnobacterium ↑3
Bacteroidia	Bacteroidales ↑1↑3↓5	Prevotellaceae ↓1↑3	Prevotella ↓1↑2↑3
		Rikenellaceae −1
		Porphyromonadaceae ↓1↓5	Parabacteroides ↓1↑3↑5
			Barnesiella ↓1
		Bacteroidaceae ↓1	Bacteroides ↓1−2−3−4↑5
Betaproteobacteria	Burkholderiales	Sutterellaceae ↓1	Parasutterella ↑1↓3
Clostridia ↑1	Clostridiales ↓5	Lachnospiraceae ↑1↑3−5	Roseburia ↑3
		Ruminococcaceae −2↑3−5	Faecalibacterium ↑3
		Clostridiaceae	Clostridium ↑2↑3(XI Cluster) ↓5(XIVa Cluster) ↑5
			Candidatus Arthromitus ↑3
			Candidatus Savagella ↑4
		Eubacteriaceae	Eubacterium (rectale) ↑4
		Oscillospiraceae	Oscillibacter ↑1
		Peptococcaceae ↑3
Delta Proteobacteria	Desulfovibrionales ↑1	Desulfovibrionaceae −5	Lawsonia −5
			Desulfovibrio −5
Epsilonproteobacteria	Campylobacterales	Helicobacteraceae	Helicobacter ↑2↑3
Erysipelotrichia	Erysipelotrichales	Erysipelotrichaceae ↑3↑5	Turicibacter ↑3
			Allobaculum −3↓5
Gammaproteobacteria	Enterobacterales	Enterobacteriaceae ↑3	Escherichia ↓2
			Enterobacter ↓1
		Morganellaceae	Proteus ↓2
	Pseudomonadales	Moraxellaceae	Psychrobacter ↑3
			Acinetobacter ↑3
	Xanthomonadales	Xanthomonadaceae	Stenotrophomonas ↑3
Negativicutes	Acidaminococcales	Acidaminococcaceae	Phascolarctobacterium ↑3
	Veillonellales	Veillonellaceae ↑3
Verrucomicrobiae	Verrucomicrobiales	Akkermansiaceae	Akkermansia ↓1↑3↑5
		Verrucomicrobiaceae ↓1

Increased (↑), decreased (↓) and unaltered (−) intestinal bacterial proportions are indicated in:

¹hepatocyte specific REG3α transgenic mice[79].

²intestinal cell specific Reg4 knockout mice[16].

³intestinal cell specific REG3γ transgenic mice[80].

⁴the intestinal mucosa of Reg3γ knockout mice[31].

⁵the intestinal mucosa of Reg3β knockout mice[35].