Retrospective Study
Copyright ©The Author(s) 2020.
World J Gastroenterol. May 14, 2020; 26(18): 2221-2231
Published online May 14, 2020. doi: 10.3748/wjg.v26.i18.2221
Table 4 Hazard ratio for the different variables investigated by univariate analysis and multivariate analysis as possible prognostic factors in 188 cirrhotic patients presenting with hepatic encephalopathy and commenced on rifaximin
VariableUnivariate hazard ratio using cox regression (95%CI)1Multivariate hazard ratio (95%CI)1
Age1.014 (0.99, 1.03)
Sex (male vs female)1.087 (0.75, 1.58)
Aetiology of cirrhosis2
HBV infection0.76 (0.28, 2.05)
HCV infection0.62 (0.42, 0.91)a
Alcohol0.92 (0.65, 1.30)
Precipitating factors2
Gastrointestinal bleed0.75 (0.46, 1.22)
Infection1.49 (1.03, 2.15)a
Diuretic therapy1.47 (0.94, 2.32)
Constipation1.19 (0.73, 1.95)
Ascites at the time of HE21.11 (0.77, 1.59)
Maximal grade of HE (grade 3 and 4 vs grade 1 and 2)0.80 (0.53, 1.21)
Serum values3
Bilirubin1.001 (1, 1.002)a
ALT1 (0.99, 1.003)
GGT1 (1, 1)
Albumin0.97 (0.95, 1.002)
Urea1.05 (1.02, 1.09)a
Creatinine1.001 (1, 1.002)a
Sodium0.99 (0 .97, 1.03)
Potassium1.16 (0.96, 1.40)
INR1.5 (1.21, 1.85)a1.27 (1.04, 1.54)a
Hb0.98 (0.97, 1.01)
WCC1.06 (1.02, 1.10)a
Plt1.00 (0.99, 1.01)
Child Pugh Score (C vs A/B)1.57 ( 1.02, 2.41)a
MELD1.03 (1.01, 1.06)a
MELD (≥ 15 vs ≤ 15)2.41 ( 1.20. 4.85)a2.17 (1.07, 4.43)a