Folic acid attenuates high-fat diet-induced steatohepatitis via deacetylase SIRT1-dependent restoration of PPARα

Table 2 Serological lipid metabolism indexes in each group

	Control	HFD	Folic acid
ALT (U/L)	38.50 ± 1.58	134.0 ± 8.02b	82.13 ± 7.19d
AST (U/L)	88.00 ± 4.39	225.4 ± 10.57b	176.3 ± 15.3d
FBG (mmol/L)	10.45 ± 0.66	13.33 ± 0.40b	7.83 ± 0.30d
TG (mmol/L)	0.57 ± 0.04	0.76 ± 0.04b	0.44 ± 0.02d
TC (mmol/L)	1.13 ± 0.04	2.26 ± 0.12b	1.48 ± 0.04d
HDL (mmol/L)	0.94 ± 0.03	0.75 ± 0.05b	0.74 ± 0.04
LDL (mmol/L)	0.24 ± 0.02	1.37 ± 0.10b	0.89 ± 0.03d
TBA (µmol/L)	37.5 ± 5.57	68 ± 7.49b	44.17 ± 3.92c
Hcy (µmol/L)	7.35 ± 0.29	13.05 ± 0.52b	11.17 ± 0.42d

The data are expressed as the mean ± SE (n = 5-8).

^bP < 0.01 vs Control group.

^cP < 0.05 vs HFD group.

^dP < 0.01 vs HFD group. HFD: High-fat diet; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; FBG: Fast blood glucose; TG: Triglycerides; TC: Total serum cholesterol; HDL: High density lipoprotein; LDL: Low density lipoprotein; TBA: Total bile acids; Hcy: Homocysteine.