Usefulness of autotaxin for the complications of liver cirrhosis

Table 2 Area under the receiver operator characteristic curves

Item	Parameter	Male	Female
		AUC (95%CI)	AUC (95%CI)
Hepatic encephalopathy	ATX	0.853 (0.795-0.911)	0.759 (0.658-0.860)
	MELD	0.644 (0.563-0.725)	0.727 (0.640-0.814)
	Fib 4 index	0.651 (0.568-0.734)	0.674 (0.538-0.789)
	APRI	0.670 (0.590-0.750)	0.640 (0.516-0.778)
	ALBI	0.825 (0.757-0.893)	0.815 (0.685-0.811)
Hepatic ascites	ATX	0.816 (0.756-0.877)	0.717 (0.616-0.819)
	MELD	0.640 (0.560-0.720)	0.744 (0.665-0.823)
	Fib 4 index	0.654 (0.569-0.738)	0.653 (0.540-0.765)
	APRI	0.663 (0.581-0.744)	0.633 (0.520-0.746)
	ALBI	0.863 (0.807-0.918)	0.787 (0.690-0.878)
Varix rupture	ATX	0.706 (0.558-0.855)	0.697 (0.512-0.882)
	MELD	0.514 (0.386-0.643)	0.612 (0.413-0.810)
	Fib 4 index	0.619 (0.462-0.775)	0.566 (0.299-0.833)
	APRI	0.653 (0.474-0.833)	0.579 (0.333-0.826)
	ALBI	0.608 (0.449-0.768)	0.614 (0.524-0.803)

The area under the receiver operating characteristic curves of autotaxin in men were higher than those in women and higher than those using other biomarkers for detecting encephalopathy and varix rupture. ATX: Autotaxin; Fib-4: Fibrosis-4; ALBI: Albumin-bilirubin index; MELD: Model for end-stage liver disease; APRI: Aspartate aminotransferase-to-platelet ratio index. AUC: Area under the receiver operating characteristic curve; CI: Confidence interval.