Conventional therapy for moderate to severe inflammatory bowel disease: A systematic literature review

Table 11 Individual studies included for maintenance of clinical remission in ulcerative colitis

Study	Country	Intervention	Comparator	Study design	Follow-up	n	Maintenance of clinical remission
Sood et al[32]	India	AZA	-	Retrospective cohort	12 mo	111	91%1
		AZA	-	Retrospective cohort	24 mo	N/A	88%1
		AZA	-	Retrospective cohort	36 mo	N/A	76%1
		AZA	-	Retrospective cohort	48 mo	N/A	53%1
		AZA	-	Retrospective cohort	60 mo	N/A	38%1
Campbell et al[35]	United Kingdom	Cyclosporine	-	Retrospective cohort	1 yr	76	35%2
		Cyclosporine	-	Retrospective cohort	3 yr	N/A	10%2
Arts et al[36]	Belgium	Cyclosporine	-	Retrospective cohort	1 yr	34	27.8%3
		Cyclosporine	-	Retrospective cohort	3 yr	5	50%3
Hyde et al[44]	United Kingdom	Cyclosporine	-	Retrospective cohort	19 mo	50	40%4
Meyers et al[42]	United States	ACTH	Hydrocortisone	RCT	1 yr	66	37.5% (ACTH); 23.5% (hydrocortisone)5

¹Remission was defined as absence of symptoms of active disease as rectal bleeding and normal bowel frequency and hence no need for steroids for at least 6 mo;

²Maintenance of remission defined as absent of disease relapse;

³The study does not present the exact definition considered for clinical remission;

⁴Remission defined as bowel frequency less than three stools per day, no visible blood, no fever or pain;

⁵Therapeutic success was considered as a clinical remission, defined by the absence of all symptoms and the reduction of the frequency of bowel movements to two or less per day. ACTH: Adrenocorticotrophic hormone; AZA: Azathioprine; n: Number of patients; N/A: Not available; RCT: Randomized clinical trial.