Targeted and immune therapies for hepatocellular carcinoma: Predictions for 2019 and beyond

Table 2 Randomized phase II, phase III clinical trials of early / intermediate stage hepatocellular carcinoma

Target population		Design	Trial name	Result	Presentation	Publication	1st author
Early	Adjuvant (prevention of recurrence)	1 Vitamin K2 vs Placebo		Negative		Hepatology 2011[21]	Yoshida H
		2 Peretinoin vs Placebo	NIK-333	Negative	ASCO 2010	JG 2014[22]	Okita K
		3 Sorafenib vs Placebo	STORM	Negative	ASCO 2014	Lancet-O 2015[23]	Bruix J
		4 Peretinoin vs Placebo	NIK-333/K-333	Ongoing
	Improvement of RFA	1 RFA +/- LTLD	HEAT	Negative	ILCA 2013	CCR 2017[24]	Tak WY
		2 RFA +/- LTLD	OPTIMA
Intermediate	Improvement of TACE	1 TACE +/- Sorafenib	Post-TACE	Negative	ASCO-GI 2010	EJC 2011[25]	Kudo M
		2 TACE +/- Sorafenib	SPACE (Ph II)	Negative	ASCO-GI 2012	J Hepatol 2016[26]	Lencioni R
		3 TACE +/- Brivanib	BRISK-TA	Negative	ILCA 2013	Hepatol 2014[27]	Kudo M
		4 TACE +/- Orantinib	ORIENTAL	Negative	EASL 2015	Lancet GH 2017[28]	Kudo M
		5 TACE +/- Sorafenib	TACE-2	Negative	ASCO 2016	Lancet GH 2017[29]	Meyer T
		6 TACE +/- Sorafenib	TACTICS (Ph II)	Positive	ASCO-GI 2018[30]		Kudo M

LTLD: Lyso-thermosensitive liposomal doxorubicin.