Diagnostic and prognostic value of lncRNA cancer susceptibility candidate 9 in hepatocellular carcinoma

Table 5 The top 10 Gene Ontology enrichment functions

Term	Count	P value	Genes
Negative regulation of transcription from the RNA polymerase II promoter	9	0.001	PHF19, SQSTM1, CPEB3, E2F7, ESR1, CBX2, SOX6, HMGA2, TWIST1
Positive regulation of transcription regulatory region DNA binding	3	0.002	WNT3A, HMGA2, TWIST1
Cytoplasm	27	0.003	CLSPN, CPEB3, TPM2, BDNF, RNF165, MAPT, STRIP2, HOXA10, FASN, PLCB1, CDC37L1, ARL2, IRAK1, SGK1, MAP2K1, KIF5A, DDX39B, PIM1, SOCS6, ESR1, SNAI2, WEE1, CDC25A, ADM, CA8, PSAT1, DUSP6
Positive regulation of transcription, DNA-templated	6	0.009	RET, MAP2K1, FOXK1, MYRF, ESR1, PLCB1
Osteoblast differentiation	4	0.010	WNT3A, FASN, SNAI2, TWIST1
Neuron projection morphogenesis	3	0.011	BDNF, SGK1, WEE1
Transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific	5	0.019	PLAG1, HOXA10, ESR1, HMGA2, MYBL2
Negative regulation of sequence-specific DNA binding transcription factor activity	3	0.021	PIM1, ESR1, TWIST1
Neuron projection	4	0.027	CPEB3, KIF5A, MAPT, SLC6A4

PHF19: PHD finger protein 19; SQSTM1: Sequestosome 1; CPEB3: Cytoplasmic polyadenylation element binding protein 3; E2F7: E2F transcription factor 7; ESR1: Estrogen receptor 1; CBX2: Chromobox 2; SOX6: SRY-box transcription factor 6; HMGA2: High mobility group AT-hook 2; TWIST1: Twist family bHLH transcription factor 1; WNT3A: Wnt family member 3A; CLSPN: Claspin; TPM2: Tropomyosin 2; BDNF: Brain derived neurotrophic factor; RNF165: Ring finger protein 165; MAPT: Microtubule associated protein tau; STRIP2: Striatin interacting protein 2; HOXA10: Homeobox A10; FASN: Fatty acid synthase; PLCB1: Phospholipase C beta 1; CDC37L1: Cell division cycle 37 like 1; ARL2: ADP ribosylation factor like GTPase 2; IRAK1: Interleukin 1 receptor associated kinase 1; SGK1: Serum/glucocorticoid regulated kinase 1; MAP2K1: Mitogen-activated protein kinase kinase 1; KIF5A: Kinesin family member 5A; DDX39B: DExD-box helicase 39B; PIM1: Pim-1 proto-oncogene, serine/threonine kinase; SOCS6: Suppressor of cytokine signaling 6; SNAI2: Snail family transcriptional repressor 2; WEE1: WEE1 G2 checkpoint kinase; CDC25A: Cell division cycle 25A; ADM: Adrenomedullin; CA8: Carbonic anhydrase 8; PSAT1: Phosphoserine aminotransferase 1; DUSP6: Dual specificity phosphatase 6; RET: Ret proto-oncogene; FOXK1: Forkhead box K1; MYRF: Myelin regulatory factor; PLAG1: PLAG1 zinc finger; MYBL2: MYB proto-oncogene like 2; SLC6A4: Solute carrier family 6 member 4.