Increased circulating circular RNA_103516 is a novel biomarker for inflammatory bowel disease in adult patients

Table 6 Univariate logistic regression analysis showing the disease phenotypes of ulcerative colitis in correlation to circular RNA_103516 status as dependent variable

Clinical variable	n	CircRNA_103765 + (%)	Crude			Adjusted
			OR	95%CI	P value	OR	95%CI	P value
Gender
Male	38	52.6%
Female	52	59.6%	1.329	0.571-3.090	0.509	NS
Age
< 40 yr	40	60.0%
≥ 40 yr	50	54.0%	0.783	0.337-1.817	0.568	NS
Smoking status
Never	67	69.7%
Past or current use	23	47.8%	0.619	0.239-1.604	0.323	NS
Disease location of UC
E1	36	44.4%
E2	30	60.0%	1.875	0.702-5.009	0.210	NS
E3	24	70.8%	3.036	1.012-9.107	0.048
Disease severity of UC
Mild	30	60.0%
Moderate	31	70.9%	1.630	0.562-4.729	0.369	NS
Severe	15	93.3%	9.333	1.080-80.627	0.042	10.803	1.171-94.687	0.036
Medications: n (%)
5-ASA	87	57.5%	0.786	0.143-2.037	0.342	NS
Corticosteroids	41	70.7%	1.827	0.762-5.234	0.084	NS
Immunosuppressants	14	71.4%	1.234	0.673-3.238	0.705	NS
Anti-TNF-α	4	50.0%	0.385	0.051-2.919	0.355	NS
Surgery	1	0.0%	0.000	0.000-	1.000	NS

The data are shown with crude and adjusted odds ratios and 95% confidence intervals accordingly. E1: Rectum; E2: Left side; E3: Extensive; UC: Ulcerative colitis; 5-ASA: 5-aminosalicylic acid; TNF-α: Tumor necrosis factor α; NS: No significance; OR: Odds ratios; CI: Confidence intervals; CircRNA: Circular RNA.