Increased circulating circular RNA_103516 is a novel biomarker for inflammatory bowel disease in adult patients

Table 4 Receiver-operating characteristic analysis of circular RNA_103516 in peripheral blood mononuclear cells from inflammatory bowel disease

Group	AUC (95%CI)	P value	Cutoff value	Sensitivity (95%CI)	Specificity (95%CI)	PPV	NPV	LR +	LR -	Diagnostic accuracy
CD vs HC	0.790 (0.722-0.857)	< 0.001	1.412	66.67 (55.95%-76.26%)	78.75 (68.17%-87.11%)	77.63%	67.02%	3.137	0.423	71.76%
UC vs HC	0.687 (0.608-0.767)	< 0.001	1.151	66.67 (55.95%-76.26%)	62.50 (50.96%-73.08%)	66.67%	62.50%	1.778	0.533	64.71%
CD vs UC	0.631 (0.550-0.712)	0.002	1.963	54.44 (43.6%- 64.98%)	68.89 (58.26% to 78.23%)	55.05%	55.75%	1.750	0.661	59.41%

AUC: Area under the curve; CD:Crohn’s disease; UC: Ulcerative colitis; HC: Healthy control; PPV: Positive predictive value; NPV: Negative predictive value; LR +: Positive likelihood ratio; LR -: Negative likelihood ratio.