Review
Copyright ©The Author(s) 2019.
World J Gastroenterol. Nov 7, 2019; 25(41): 6172-6189
Published online Nov 7, 2019. doi: 10.3748/wjg.v25.i41.6172
Table 3 Therapeutic drug monitoring-based algorithm for handling patients with treatment failure on biologic therapy[59-61]
Detectable anti-drug antibodiesUndetectable anti-drug sntibodies
Sub-therapeutic anti-TNF drug levelsChange to different TNF-inhibitor.Intensify the treatment regimen of the currently used TNF-inhibitor.
Therapeutic anti-TNF drug levels(Repeat assessments of anti-TNF drug and anti-drug antibodies over time) Switch to another biological agent with a different mechanism of action.Switch to another biological agent with a different mechanism of action.